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Molecular Medicine
Found: 101
Background. Congenital heart defects can be embryopathies formed due to an imbalance in the processes of differentiation and proliferation in cardiac progenitor cells. One of the reasons for these disorders may be genetically restricted signaling, including th…
Introduction. Viral infections induce cellular and humoral immunity that provide virus elimination. Extracellular presentation of antigens of formaldehyde-inactivated vaccines causes mainly humoral immune response with risk of persistent infection. The aim of …
Introduction. Early diagnostics of such oncological disease as cutaneous malignant melanoma is strictly important for the decrease of mortality. It is known that microRNA expression in melanoma cells and in bening melanocytic nevi is different, that can be use…
Introduction. The human microbiota is part of the «human-microbiome» system and is actively involved in developing various pathological responses and conditions in the body. It is currently essential to study the pathogenesis of ulcerative colitis (UC), a poly…
Introduction. Under the influence of glioma cells, peritumoral zone astrocytes may acquire tumorigenic phenotype, particularly due to the suppression of immunocompetent cells. The aim of the study. Investigate the changes in the gene expression profile of glio…
Introduction: nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. But it remains unclear what factors influence the progression of the disease. It is interesting to study the influence of the genetic aspect on the course of NAF…
Introduction. Aging is associated with a decrease in the neuro- and synaptogenesis as well as hyperactivation of glial cells, which leads to changes in the morphofunctional state of the nervous tissue of the hippocampus and, as a consequence, a deterioration i…
Introduction. The formation of neurofibrillary plexuses and the accumulation of senile plaques in the parenchyma and cerebral vessels are the key pathological signs of Alzheimer’s disease presenting a neurodegenerative disease. The main component of senile pla…
Introduction. Degenerative retinal diseases are considered as the leading cause of blindness and low vision worldwide. The last studies have provided convincing evidence of the involvement of immunological factors in the development and progression of the dise…
Introduction. Patients with surgical menopause are at risk for an osteopenic syndrome. For adequate medical correction of osteoporosis, it is necessary to clarify the mechanisms of the pathogenesis of this condition. It is known that osteoclasts, the activatio…
Introduction. The molecular mechanisms of the development of tumor pathology of the thyroid gland are associated with the activation of angiogenesis and the development of hypoxia, which contributes to the proliferation, invasion, and progression of the diseas…
Introduction. The single-nucleotide polymorphisms rs75555045 and rs12904699 were found in the own genome-wide allelotyping as possible new molecular genetic markers of sudden cardiac death (SCD). The results obtained in such studies require verification in the…
Introduction. Successful embryonic development immediately after fertilization depends on the maternal messenger RNAs (mRNAs) destruction and zygotic genome transcription activation during maternal to zygotic transition (MZT). Key regulators of MZP are small n…
Introduction. Thyroid cancer (TC) is the most prevalent cancer among malignant neoplasms of the organs of the endocrine system. Cytological categories Bethesda III–V of TC are considered to be the most difficult for making a diagnosis. Molecular genetic tests …
Introduction. Patients with surgical menopause are at risk for an osteopenic syndrome. For adequate medical correction of osteoporosis, it is necessary to clarify the mechanisms of the pathogenesis of this condition. It is known that osteoclasts, the activatio…
Introduction. Hemophilia A is a frequent X-linked recessive disorder associated with the absence or functional defect of blood clotting factor VIII. Вoth point mutations and large structural rearrangements – deletions, duplications, and inversions were describ…
Introduction. New directions of the modern cell biology are the development of methods for reprogramming stem cells into differentiated ones and reverse reprogramming of differentiated cells into stem cells. Transient processes in cells from the one stable sta…
Introduction. Psoriasis is a chronic inflammatory autoimmune disease with complex etiology including inheritable factors as well. Some scientists suggest psoriasis to be a systemic disease affecting not only skin. Thus, on the edge of dermatology and psychiatr…
Aim. To study the intergenic interaction and estimate the contribution of polymorphic loci p.K23E (rs5219, KCNJ11), g.15661G>T (rs1501299, ADIPOQ), p.V109D (rs2274907, ITLN1), g.2453G>A (rs7799039, LEP), g.53341C>T (rs7903146, TCF7L2), and p.P12A (rs1801282, P…
Introduction. The telomerase reverse transcriptase gene (TERT) promoter region is frequently mutated in different types of cancer. Several studies have shown patients who carry the mutation –245T>C (rs2853669) to have a worse prognosis. The aim of the study is…