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Molecular Medicine Peer-reviewed scientific journal

Found: 24

Research article2013

ANALYSIS OF GENETIC POLYMORPHISMS IN ESTROGENMETABOLIZING ENZYMES IN OVARIAN CANCER PATIENTS IN THE SIBERIA REGION

Early diagnosis of ovarian cancer (OC) remains to be the actual problem in modern oncology due to the high mortality rate, asymptomatic course of the disease in the early stages and its aggressiveness. The aim was to study the genetic polymorphism of pathogene…

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Research article2013

THE MECHANISM OF TOLERANCE OF THE ESTROGEN-INDEPENDENT BREAST CANCER CELLS TO HYPOXIA:THE ROLE OF SNAIL1 AND BETA-CATENIN, THE EPITHELIAL-MESENCHYMAL TRANSITION PROTEINS

The main goal of the project was to study the heightened tolerance of the resistant breast cancer cells to hypoxia. Two in vitro cultured breast cancer cell lines, the estrogen-dependent MCF-7 cells and the resistant ER-negative HBL-100 cells were used in the …

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Research article2013

MOLECULAR CHARACTERIZATION OF UTERINE LEIOMYOMA ACCORDINGTO EXPRESSION OF GENES OF STEROID RECEPTORS, STS, SULT AND PTEN

Leiomyoma is one of the most common benign tumors of the female reproductive system. As this pathology in most cases is hormone dependent, we determined the level of gene expression of steroid receptors ERs, PR, estrogen sulfotransferase SULT1E1, STS steroid s…

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