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Molecular Medicine
Found: 29
Introduction. The pathogenesis of inflammatory bowel disease is complex and multifactorial. Studies have led to the current concept that the T-helper cells are components of the adaptive immune response whereas Toll-like receptors, NOD-like-receptors, RIG-I-li…
Introduction. RANK/RANKL/OPG ligand-receptor system is a key player in bone tissue homeostasis directly regulating osteoclast differentiation and osteolysis. Many pathologic processes imposed by impairments in bone remodeling including tumor growth and metasta…
The paper is devoted to the history of the discovery of a new class of signaling molecules – kisspeptins and analysis of current ideas on their biological role. KISS1 gene was first described in 1996 as a gene which prevents metastasis of tumor cells. In the f…
IL15 proves to be a cytokine that important for innate as well as for adaptive immunity. It is one of the key factors of cell-mediated antiviral response. In this review we touch upon its primary, secondary and tertiary structure and functions, characteristics…
«Nothing in biomedicine makes sense except in the light of evolution». From this point of view, genetics of predispositions hasto answer two basic questions: 1. Is the natural genetic polymorphism identified with modern genomics proved to be the result of neut…
Regulatory T-cells CD4+CD25+FoxP3+CD127low (Тregs) belong to the family of CD4+ T-cell subpopulation. Tregs display the suppressive activity and play a critical role in regulation and maintenance of autotolerance and immune homeostasis. The generation and diff…
RANK/RANKL/OPG system – is a key element in bone homeostasis. In this review we depict the basic principles of functioning of this system and known genetical anomalies affecting its components. Also we describe a number of pathological states associated with d…
The expression of signal molecules RON, CD90, CD73, СD64, Pax6, Chx10, RTF1, Oct2, which characterized the status of local and system homeostasis have been verified in the buccal epithelium from women with breast cancer. The most important markers, correlated …
Introduction. Buccal epithelium (BE), in which cells the expression of signal molecules reflecting the state of homeostasis of the body in normal and pathological conditions is verified, is used as a diagnostic material for a number of diseases in adults. The …