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Molecular Medicine Peer-reviewed scientific journal

Molecular Medicine

RANK/RANKL/OPG SYSTEM IN BONE METASTASES AND PRIMARY BONE TUMORS

Kushlinskii N.E., Timofeev Yu.A., Gershtein E.S.

Authors and affiliations

N.E. Kushlinskii, Yu.A. Timofeev, E.S. Gershtein
N.N. Blokhin Russian Cancer Research Center, Moscow

Published
2013

Abstract

RANK/RANKL/OPG system – is a key element in bone homeostasis. In this review we depict the basic principles of functioning of this
system and known genetical anomalies affecting its components. Also we describe a number of pathological states associated with disorders in
RANK/RANKL/OPG system and consider the role of this system in development of bone metastases and in primary bone tumors.

Keywords

Authors and affiliations

N.E. Kushlinskii, Yu.A. Timofeev, E.S. Gershtein
N.N. Blokhin Russian Cancer Research Center, Moscow

How to cite

Kushlinskii N.E., Timofeev Yu.A., Gershtein E.S. (2013). RANK/RANKL/OPG SYSTEM IN BONE METASTASES AND PRIMARY BONE TUMORS. Molecular Medicine, (6).

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