Table of contents
Articles
CLINICAL SIGNIFICANCE OF EPIDERMAL GROWTH FACTORS AND SEX STEROIDS IN ENDOMETRIAL TUMORS
The study data of the epidermal growth factor receptors(EGFR), estrogen and progesterone receptors(ER, PR) in the endometrial tumors in 125 patients are presented. EGFR have been detected in 40% of tumors. The EGFR–RP+ER+ tumors were detected most frequently (…
MOLECULAR CHARACTERIZATION OF UTERINE LEIOMYOMA ACCORDINGTO EXPRESSION OF GENES OF STEROID RECEPTORS, STS, SULT AND PTEN
Leiomyoma is one of the most common benign tumors of the female reproductive system. As this pathology in most cases is hormone dependent, we determined the level of gene expression of steroid receptors ERs, PR, estrogen sulfotransferase SULT1E1, STS steroid s…
CONTENT OF EPIDERMAL GROWTH FACTOR RECEPTORS AND ITS LIGANDS IN OVARIAN TUMORS
Results of radioligand determination of epidermal growth factor receptor (EGFR) and radioreceptor assessment of EGF-like peptides’ (EGFLP) levels in the tumors of 44 ovarian cancer and 10 benign ovarian tumor patients are presented. Frequency of revelation and…
GRADE OF MALIGNANCY AND PROGNOSIS OF WELL-DIFFERENTIATEDNEUROENDOCRINE TUMORS OF THE GASTROINTESTINAL TRACT
To study the correlation of proliferative activity of tumor cells with clinical and morphological parameters and indices of survival rates a retrospective clinical and morphological analysis of 60 cases of localized and metastatic neuroendocrine tumors (NETs) …
EGFR AND KRAS MUTATIONS IMPORTANT FOR NON-SMALL CELL LUNG CANCER TARGET THERAPY
Last successful results in target therapy of cancer were achieved with different tyrosine kinases inhibitors (TKI). Target therapy of non-small cell lung cancer (NSCLC) with EGFR inhibitors gefitinib and erlotinib is effective only in patients with somatic mut…
THE STUDY OF TOXIC AND ALLERGENIC PROPERTIES OF THE NEW PHARMACEUTICAL COMPOSITIONOF DIINDOLYLMETHANE
Preclinical experimental study of toxic and allergenic properties of new pharmaceutical composition of diindolylmethane was carried on in various doses. It was established that tested drug refers to toxicity class V (almost non-toxic pharmaceutical substance) …
MATRIX METALLOPROTEINASES AND THEIR TISSUE INHIBITORSIN OVARIAN CANCER CLINICAL COURSE AND PROGNOSIS
Publications devoted to the role of various representatives of matrix metalloproteinases (MMPs) family and their tissue inhibitors in ovarian cancer in differential diagnostics, prognosis and in the development of new treatment modalities are critically analyz…
MOLECULAR BIOMARKERS OF PANCREATIC DUCTAL ADENOCARCINOMA AND THEIR USEFULNESS IN CLINICAL PRACTICE
Ductal adenocarcinoma is the most common type of pancreatic tumors that is notable for its highly aggressive phenotype, difficulties in diagnosis establishing, exceptionally unfavorable prognosis and resistance to standard methods of therapy . The development …
RANK/RANKL/OPG SYSTEM IN BONE METASTASES AND PRIMARY BONE TUMORS
RANK/RANKL/OPG system – is a key element in bone homeostasis. In this review we depict the basic principles of functioning of this system and known genetical anomalies affecting its components. Also we describe a number of pathological states associated with d…
VASCULAR ENDOTHELIAL GROWTH FACTOR AND COMPONENTS OF PLASMINOGEN ACTIVATION SYSTEMIN ENDOMETRIAL CANCER: CLINICO-MORPHOLOGICAL CORRELATIONS
The content of VEGF and some components of plasminogen activation system (uPA, PAI-1 and tPA) was determined by enzyme immunoassay methods in the tumors from 121 endometrial cancer patients and in 18 samples of endometrial hyperplasia. Concentrations of uPA an…