Table of contents
Articles
DIFFUSE PARENCHYMAL LUNG OSTEODYSTROPHY – IDIOPATHIC INTERSTITIAL LUNG DISEASE (ILD),WITH THE DEFEAT OF THE BRONCHIOLAR ALVEOLAR TRANSITION ZONE (BATZ)
Based on literature data and analysis of own observation the hypothesis of pathogenesis of diffuse parenchymal lung osteodystrophy (DPLOD) is proposed. DPLOD is a very rare disease with unknown etiology. It is characterized by unilateral or bilateral lesions o…
METHODS OF THE SENSOR SURFACE FUNCTIONALIZATION BY BIOLOGICAL MOLECULES
There are many applications of biosensors in biochemical analysis. High specifity of biorecognizing element that allows to carry out a quantitative analysis of complex analytes with high accuracy and to detect ultrasmall concentration of the certain molecules …
THE ROLE OF SIGNALING MOLECULES IN PATHOGENESIS OF GASTROINTESTINAL TRACT DISEASES:OPTIMIZATION OF DIAGNOSTICS AND TARGET THERAPY
The review is devoted to the role of some signaling molecules produced by neuroendocrine and immune cells of the gastrointestinal tract (GIT) in the pathogenesis of the diseases of the digestive system. Special attention is paid to the key signaling molecules …
NEUROENDOCRINE TUMORS OF PANCREAS: MOLECULAR MECHANISMS OF ONCOGENESIS AND TARGETED THERAPY
In the article a review of recent data on the molecular nature of neuroendocrine tumors of the pancreas (pancreatic NETs) is presented. The genetic basis of inherited syndromes associated with the development of pancreatic NETs: multiple endocrine neoplasia ty…
PREDICTION OF HEMORRHAGIC SYNDROME IN HEMATOLOGICAL PATIENTS ON THE BASISOF FLUORESCENCE ANALYSIS OF MORPHO-FUNCTIONAL STATUS OF PLATELETS
The morphological and functional study of platelets stained with vital fluorochrome dyes has been performed in the blood of 100 donors and 100 hematological patients with thrombocytopenia. In hematologic patients with clinically pronounced hemorrhagic syndrome…
INFLUENCE OF PREOPERATIVE CHEMOTHERAPYON BIOLOGICAL FEATURES OF COLORECTAL CANCER LIVER METASTASES
The modern strategies of chemotherapy of metastatic colorectal cancer (CRC) based on the combination of cytotoxic and targeted angents resulted in significant increase of patient’s life duration. To study the action of anti-EGFR agents (panitumumab), which blo…
CARDIOPROTECTIVE EFFECTS OF AFOBAZOL IN ANIMALS WITH CHRONIC MYOCARDIAL ISCHEMIA
Morphometric studies of the median transverse sections of rat hearts, performed on 28th day after coronary artery ligation, showed that as a result of myocardial infarction the pronounced postinfarction remodelling of the left ventricle of the heart was observ…
EPIGENETIC EFFECTS OF MINOR GROOVE BINDING LIGANDS
The influence of the DNA minor groove binding ligands on epigenetic silencing in eukaryotic human cells has been demonstrated for the first time. Using HeLa cell population that harbors silent GFP-reporter gene under control of the CMV promoter we demonstrated…
REGULATION OF THE ACTIVITY OF DRUG METABOLISM ENZYMES –CYTOCHROMES P450 3A4 AND 2C9 BY BIOLOGICALLY ACTIVE COMPOUNDS
A study of the influence of vitamins with antioxidant properties (vitamins A, E, C, coenzyme Q10), drugs, antioxidants (etoksidol, meksidol, cytochrome c), B vitamins (В1, В2, В6), and vitamin-like substances taurine and L-carnitine on the phase I xenobiotic-m…
THE STUDY OF THE STRUCTURE - ANTIARRHYTHMIC ACTIVITY RELATIONSHIP AMONGN-[2-(1-ADAMANTYLAMINO)-2-OXOETHYL]-N-( ω-AMINOALKYL) AMIDES OF NITROBENZOIC ACIDS
The original selective blocker of voltage-transmembrane potassium channels pharmacological drug cardiocyclide (N-[2-(dicyclohexylamino)- 2-oxoethyl]-N-[3-(diethylamino)propyl]-4-nitrobenzoic carboxamide hydrocloride) has been earlier synthesized and pharmacolo…
MOLECULAR MODELING, SYNTHESIS AND EVALUATION OF THE BIOLOGICAL ACTIVITYOF NEW GLYCOPROTEIN IIB/IIIA (GPIIB/IIIA) RECEPTOR ANTAGONISTS
We applied software «Algokomb» to perform mathematical modeling of polypeptide molecules of glycoprotein IIb/IIIa (gpIIb/IIIa) receptor antagonists. The modeled compounds have been synthesized accordingly to the protocol of strategy FastMoc 0.25. The structure…