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We applied software «Algokomb» to perform mathematical modeling of polypeptide molecules of glycoprotein IIb/IIIa (gpIIb/IIIa)
receptor antagonists. The modeled compounds have been synthesized accordingly to the protocol of strategy FastMoc 0.25. The structure of
the compounds has been confirmed by LCMS, 1H NMR and 1Н/1Н (COSY, NOESY) NMR methods. The evaluation of the specificity of the
synthesized compounds has been made in vitro and has shown dose-dependent reduction of ADP-induced platelet aggregation.
А.А. Alekseev (1), M.I. Brylev (1), V.L. Korolev (1), D.S. Lotorev (1), А.Yu. Lizunov (2), Е.А. Batuev (3), L.А. Pavlova (1)
1 -Sechenov First Moscow State Medical University, 2 -Moscow Institute of Physics and Technology (State University), 3 -Lomonosov Moscow State University
How to cite
Alekseev A.A., Brylev M.I., Korolev V.L., Lotorev D.S., Lizunov A.Yu., Batuev E.A., Pavlova L.A. (2013). MOLECULAR MODELING, SYNTHESIS AND EVALUATION OF THE BIOLOGICAL ACTIVITYOF NEW GLYCOPROTEIN IIB/IIIA (GPIIB/IIIA) RECEPTOR ANTAGONISTS. Molecular Medicine, (5).
Alekseev A.A., Brylev M.I., Korolev V.L., Lotorev D.S., Lizunov A.Yu., Batuev E.A., Pavlova L.A., “MOLECULAR MODELING, SYNTHESIS AND EVALUATION OF THE BIOLOGICAL ACTIVITYOF NEW GLYCOPROTEIN IIB/IIIA (GPIIB/IIIA) RECEPTOR ANTAGONISTS”, Molecular Medicine, no. 5, 2013.
Alekseev A.A., Brylev M.I., Korolev V.L., Lotorev D.S., Lizunov A.Yu., Batuev E.A., Pavlova L.A. “MOLECULAR MODELING, SYNTHESIS AND EVALUATION OF THE BIOLOGICAL ACTIVITYOF NEW GLYCOPROTEIN IIB/IIIA (GPIIB/IIIA) RECEPTOR ANTAGONISTS.” Molecular Medicine, no. 5, 2013,
Alekseev A.A., Brylev M.I., Korolev V.L., Lotorev D.S., Lizunov A.Yu., Batuev E.A., Pavlova L.A. 2013. “MOLECULAR MODELING, SYNTHESIS AND EVALUATION OF THE BIOLOGICAL ACTIVITYOF NEW GLYCOPROTEIN IIB/IIIA (GPIIB/IIIA) RECEPTOR ANTAGONISTS.” Molecular Medicine (5).
Alekseev A.A., Brylev M.I., Korolev V.L., Lotorev D.S., Lizunov A.Yu., Batuev E.A., Pavlova L.A. (2013) ‘MOLECULAR MODELING, SYNTHESIS AND EVALUATION OF THE BIOLOGICAL ACTIVITYOF NEW GLYCOPROTEIN IIB/IIIA (GPIIB/IIIA) RECEPTOR ANTAGONISTS’, Molecular Medicine, (5).
Alekseev A.A., Brylev M.I., Korolev V.L., Lotorev D.S., Lizunov A.Yu., Batuev E.A., Pavlova L.A. MOLECULAR MODELING, SYNTHESIS AND EVALUATION OF THE BIOLOGICAL ACTIVITYOF NEW GLYCOPROTEIN IIB/IIIA (GPIIB/IIIA) RECEPTOR ANTAGONISTS. Molecular Medicine. 2013;(5).
TY - JOUR
TI - MOLECULAR MODELING, SYNTHESIS AND EVALUATION OF THE BIOLOGICAL ACTIVITYOF NEW GLYCOPROTEIN IIB/IIIA (GPIIB/IIIA) RECEPTOR ANTAGONISTS
AU - Alekseev A.A.
AU - Brylev M.I.
AU - Korolev V.L.
AU - Lotorev D.S.
AU - Lizunov A.Yu.
AU - Batuev E.A.
AU - Pavlova L.A.
JO - Molecular Medicine
PY - 2013
IS - 5
UR - https://new.molmedjournal.ru/en/molecmed-2013-05-11
ER -
@article{article167,
title = {MOLECULAR MODELING, SYNTHESIS AND EVALUATION OF THE BIOLOGICAL ACTIVITYOF NEW GLYCOPROTEIN IIB/IIIA (GPIIB/IIIA) RECEPTOR ANTAGONISTS},
author = {Alekseev A.A. and Brylev M.I. and Korolev V.L. and Lotorev D.S. and Lizunov A.Yu. and Batuev E.A. and Pavlova L.A.},
journal = {Molecular Medicine},
year = {2013},
number = {5},
}
