Table of contents
Articles
ETHNIC DIFFERENCES OF THE CYP2C19 GENE POLYMORPHISM ASSOCIATED WITH THE VIOLATION OF THE RESPONSE TO CLOPIDOGREL IN THE RUSSIAN FEDERATION
Genetically determined diversity in the activity of enzymes regulating the biotransformation of drugs and xenobiotics - cytochrome P450 (CYP) is one of the main causes of interindividual differences in the response of pharmacotherapy. The objective of this rev…
MOLECULAR ESTIMATION OF MYOGENESIS AND STATE OF UTERINE SCAR AFTER MYOMECTOMY IN DIFFERENT SURGICAL APPROACHES
Introduction. Due to the impetuous development of endovideosurgery in gynecology, laparoscopic access technique is increasingly frequently used to perform myomectomy. However in the available literature until now there is no decisive opinion on the feasibility…
INCULIN-LIKE GROWTH FACTORS IN SERUM OF COLORECTAL CANCER PATIENTS
Introduction. Insulin-like growth factors (IGFs) signaling system plays a key role in development and progression of various malignant tumors, and its components may be considered as prospective diagnostic and prognostic markers and potential objects of target…
INCULIN-LIKE GROWTH FACTORS IN THE SERUM OF BREAST CANCER PATIENTS
Introduction. Breast cancer pathogenesis is associated with alterations in processes of regulating of IGF effects and also in IGF-signaling pathway activation. The direct correlation between high IGF blood serum levels and the rescue of malignancies in prostat…
THE CONTENT OF PROINFLAMMATORY CYTOKINES OF TNFα AND IL6 IN PAROTID SALIVARY FLUID IN DUCTAL CHRONIC SIALADENITIS PATIENTS
Introduction. Сhronic sialadenitis is an inflammatory salivary gland disease with unclear etiology and not fully understood pathogenesis. A special attention of researchers is paid to the study of various molecular markers secreted in the course of chronic inf…
TUMOR-ASSOCIATED METALLOPROTEINASES IN SERUM OF PRIMARY BONE SARCOMA PATIENTS
Introduction. Matrix metalloproteinase (MMP) – a family of extracellular zinc-containing proteases. There are currently 25 known MMP. Increased activity of MMP observed in some physiological processes – during the follicular phase of the menstrual cycle and du…
MATRIX METALLOPROTEINASES AND PERIODONTAL DISEASES
Introduction. The paper presents basic information about the modern role of the IMF in various biochemical processes. Emphasis is placed on the role of MMPs in the pathogenesis of periodontitis. These published data suggest ambiguity of scientific views on the…
FREE RADICAL OXIDATION OF PROTEINS AND LIPIDS IN ADIPOCYTES UNDER CONDITIONS OF OXIDATIVE STRESS
Introduction. According to the current understanding, oxidative stress plays a key role in the mechanisms of diabetes mellitus of types 1 and 2 emergence and development of its complications; formation of oxidative stress is accompanied by defective uptake of …
SOMATOSTATIN ANALOGS AS VECTOR MOLECULES FOR TARGETED DELIVERY OF ANTICANCER DRUGS
Targeted delivery of anticancer drugs is a new direction aimed to delivery preparations capable of enhancing selectivity of action of drugs owing to the use of vector molecules. Targeted drug delivery system is the construction that includes three components: …