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Molecular Medicine
Found: 33
Introduction. Age-assosiated endothelial changes are one of the reasons of the development of cardio-vascular pathology. Moreover, molecular mechanisms of human endothelium aging are investigated only slightly. Thus, the problem of pathogenesis of cardio-vascu…
Introduction. In interstitial lung diseases (ILD), characterized by inflammatory and fibrous processes, the intensification of angiogenesis also occurs. The aim of our research. Was the study of characteristics of expression angiogenic molecules (VEGF, ET1) in…
Introduction. Atherosclerosis proves to be age-dependent and social significant pathology. Knowledge of the role of signaling molecules in its development, and the elaboration on this basis molecular markers of restenosis after stenting of arteries remains to …
Neuroendocrine tumors (NETs) constitute a heterogeneous group of relatively rare neoplasms, incidence of which has increased in the last decades. These tumors are composed of cells with a neuroendocrine phenotype and may occur in any organ, but are most often …
Among oncology diseases the primary bone tumors make up to 0,7–2,0% of all malignancies. The peak of morbidity caused by bone tumors falls on the age of person’s social activity. Bone tumors are one of the most aggressive among malignant human tumors. That’s w…
Introduction. Kisspeptins (KP) are family of peptide mediators regulating function of gonadotrophic axis through the control of secretion of gonadotrophins at the central level. Also was shown that they are synthesized in other tissues and organs, where they h…
The prognosis of one of the most commonly occurring malignancies worldwide – colorectal cancer (CRC) – depends on the development of disease recurrence and distant metastases, most frequently detected in the liver. The aim of our research was to study the asso…
Diffuse large B-cell lymphoma is the most common lymphoma worldwide. Both morphologically and prognostically it represents a diverse spectrum of disease. Non-Hodgkin lymphoma of bone comprises approximately 7% of malignant bone tumors, 5% of extranodal lymphom…
Protein expression of CRABP I (Сellular Retinoic Acid Binding Protein I) was investigated by immunohistochemical analysis in pancreatic neuroendocrine tumors. Relationship of CRABPI expression to clinical features, cell proliferation activity level and metasta…
The immunohistochemical expression of MMP-2 and MMP-3 in carcinomas of the stomach, differed by product MUC1, 2, 5AС, 6 and CD10 has been investigated. In mixed carcinomas immunophenotypic variant parameters of studied MMP expression were significantly higher …
The Use of the technique of contrast enhancement in spiral computed tomography (SCT) allows us to study the peculiarities of hemodynamics in the tumor tissue and thus facilitates the differential diagnosis. Сomparison of SKT data with the results of morphologi…
Immunohystochemical examination revealed increasing of GLUT1 and decreasing of GLUT3 expression through gestation. In cases with missed abortion higher expression of GLUT1 and lower expression of GLUT3 in comparison with their expression in control group are c…
The effect of PABA in rd10 mice on photoreceptor survival, rhodopsin, blue opsin and red/green opsin contents were quantified in retinal sections using immunofluorescent techniques. The red/green cone opsin content was significantly higher in the retina of rd1…