This website is intended for professionals in medicine and healthcare. By selecting “Confirm”, I declare that I am a member of this professional audience. I also agree to the publisher’s rules for using its information resource. Publisher’s resource rules (Russian)
Molecular Medicine
Found: 39
Introduction. The delay of the adverse events by the use of drugs is an actual medicine task. The cytostatics inhibiting cellular proliferation, are using in a clinic for the hindering tumor development. Thus, the adverse events occur due to the damage of heal…
Introduction. The laboratory diagnosis of celiac disease is based on the detection of antibodies against deamidated gliadin peptides (anti-DGP), autoantibodies to tissue transglutaminase (anti-tTG) and endomysium (AEA), as well as genotyping of HLA-DQ2/8 loci.…
Peptidergic structures of the hypothalamus arrange a basis of its unique ability to regulate the organism's functions in time, adjusting metabolism, energy exchange and motor activity as sources of its own energy- to the dynamics of energy intake from external…
Introduction. Skin aging is a natural process that cannot be stopped. However, there are many ways to help stop premature aging of the skin and reduce the signs that have already appeared. One of them is the subcutaneous administration of preparations containi…
Introduction. At present, signaling pathways involved in the development of innate and adaptive immune responses and comprising, inter alia, the interaction of pattern-recognizing receptors, such as TLR, with antimicrobial peptides associated with inflammation…
Diagnosis and determination of tumor process in patients with prostate cancer are the most urgent problems of modern оncology. Prostate-specific membrane antigen (PSMA) is one of the most promising molecular targets for the diagnosis of prostate cancer. The le…
Introduction. Interaction of prosthetic devices with surrounding tissues is based on protein absorption. Protein adsorption is the first stage of the interaction between prosthetic materials with tissues in the body. The number, composition, conformation chang…
The review presents results of clinical and experimental investigations, revealed leptin’s role in the mechanisms of morphological and physiological development of the fetus and newborn. This review summarizes many of the published reports about the leptin’s r…
Introduction. The investigation of molecular and cellular mechanisms of atherosclerosis and the development of restenosis and the possibility of the regulation of these processes by short peptides opens new perspectives for the delivery of vasoprotective prepa…
Introduction. Antimicrobial peptides (AMPs) are molecules of small dimensions, consisting of about 30–40 amino acids, possessing of antiviral, antibacterial and fungicidal action. AMPs can be considered as a first barrier against pathogens in genital tract. Th…
Review is devoted to systems for drug delivery of biologically active substances in the tissues and organs of the target cells, which is relevant to medicine. There are described properties of mesenchymal stromal cells (MSCs), which many authors propose to use…
Introduction. Targeted gene delivery plays an exceptional role in the development of gene therapy. Peptide-based carriers are promising group of non-viral gene delivery vehicles due to biodegradability and easy structural and amino acid sequence modifications.…
Introduction. Biomimetic peptides – are synthetic compounds which are identical to amino acid sequence that are synthesized by organizm, which can interact with growth factor receptors and provide antiaging clinical effect. The aim of the study. Investigation …
Introduction. Cardiovascular diseases consistently occupy the first place among causes of death and disability in almost all developed countries. The main importance of this group of diseases have myocardial infarction. One of the causes of myocardial infarcti…
The lecture considers common concepts of neuroendocrine tumors (NETs). Unlike the other tumors, NETs synthesize a variety of biologically active substances (hormones, peptides, amines), that being their main feature with multiple consequences leads to the deve…
The paper is devoted to the history of the discovery of a new class of signaling molecules – kisspeptins and analysis of current ideas on their biological role. KISS1 gene was first described in 1996 as a gene which prevents metastasis of tumor cells. In the f…
Introduction. P16INK4a protein plays one of the key role in processes of cell proliferation, its inactivation is noted in a number of tumors of various localization. Restoration of the p16INK4a function in neoplastic cells may promote braking of division of tu…
We applied software «Algokomb» to perform mathematical modeling of polypeptide molecules of glycoprotein IIb/IIIa (gpIIb/IIIa) receptor antagonists. The modeled compounds have been synthesized accordingly to the protocol of strategy FastMoc 0.25. The structure…
Results of radioligand determination of epidermal growth factor receptor (EGFR) and radioreceptor assessment of EGF-like peptides’ (EGFLP) levels in the tumors of 44 ovarian cancer and 10 benign ovarian tumor patients are presented. Frequency of revelation and…