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Molecular Medicine
Found: 559
Introduction. Fibroadenomatosis (FAM) is a heterogeneous group of pathological conditions of the mo-Nochnoi gland, with hormone-dependent nature and different degree of risk maligni of the organization. The use of routine histological stains is not enough to d…
ntroduction. Agr2protein belongs to the family of disulfide isomerases of the endoplasmic reticulum and contains active cysteine domains involved in the formation of disulfide bonds with mucins. It is expressed in goblet cells of the intestinal epithelium and …
Introduction. Insulin-like growth factor (IGF) signaling system plays a major role in development and progression of various malignant tumors including colorectal cancer (CRC), so far its components are considered as potential diagnostic and prognostic markers…
Introduction authors made an attempt to demonstrate the role of DNA-methylation in pathogenesis of uterine fibroids. The epigenetic aspects based on personal investigations and literary data have been reviewed. The research underlined a perspective of investig…
Introduction. Recurrent miscarriage (RM) – a prevalent pathology in women. However, the mechanisms of its occurrence are studied insufficiently. A genetic factor may be one of the causes of RM in women. The aim of the study was to investigate the association o…
Introduction. A lot of factors of innate and specific immunity are involved in development of the autoimmune diseases – multiple sclerosis (MS) that cause the damages of myelin envelopes of nerve fibres with irreversible neurological consequences. To decrease …
Association of adrenergic receptors gene polymorphisms in overweight persons has been shown by Gagnon J. et al. in 1996. For the locus Trp64Arg (rs4994) β3-adrenoceptor gene was shown to be associated with the risk of obesity, confirmed by the works of a numbe…
Introduction. Currently questions on the role of genes polymorphism that regulate metabolism and implicated in metabolic disorders are disputed. Objective. The study of proteomic and metabolomic manifestations of different variants of apolipoprotein E genes po…
Introduction. Recent reports have demonstrated patients with malignant neoplasias have different molecular genetic aberrations. But there are few data available concerning patients with multiple primary tumors (MPT). Aim. To study molecular genetic alterations…
Background. Plasminogen activators play the leading role in the tumor growth and metastasis. Growth factors stimulate proliferative processes and are involved in neoangiogenesis. Aim of the study. Identification of changes in components of the fibrinolysis sys…
Introduction. Valvular calcification precedes the development of valvular stenosis. Currently, there being no way to effectively prevent the valvular heart disease progression, and valve replacement remains to be the only treatment option. Aim. To investigate …
Introduction. The contribution of caspase-dependent apoptosis in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is not fully understood. One possible mechanism of hepatoprotective action of ursodeoxycholic acid (UDCA) is the suppression of apopto…
Introduction. Radiotherapy becomes a standard of combination treatment of the rectal cancer. That is why the development of its pathogenetical bases is very impotent. The aim of the study. The purpose of the study was to analyze molecular and morphological eff…
Introduction. Pathogenesis of infective endocarditis (IE) is not quite clear till now. In last years research of variants of the genes connected with pathogenesis of IE was performed. The aim. The investigation of IE association with gene single-nucleotide pol…
In the context of the continuing importance of the problem of tuberculosis there must be the selection both of priority areas to combat it, and priority category of patients. The most common form of TB among new cases is infiltrative and successful treatment o…
Abstract sources: PubMed, WINITI RAS, Embase, Web of Science, Cochrane database, Current Controlled Trials for information about associations of polymorphism of genes cytokines (IL6, TNFα, IL10, TGFβ) with atherosclerosis and its complications are analyzed. As…
Introduction. Irinotekan is widely used in the treatment of oncological diseases and allows to achieve the objective answer in 35–70% of cases depending on the applied schedule of the treatment. Individual toxicity of a preparation for patients is determined b…
Introduction. Hepatitis C virus (HCV) is a major risk factor for chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Molecular mechanisms of fibrogenesis are associated with the activation or inhibition of signaling pathways, which are controlling…
Introduction. Macrophages are referred to the one of the major cell types that organize the liver regeneration. Macrophages are a heterogeneous cell population. The study of regulatory mechanisms of liver regeneration after subtotal liver resection in rats, co…
Introduction. Glycogen storage disease (GSD) type Ib is caused by mutations in the SLC37A4 gene. The aim of the study. To verify the diagnosis by molecular genetic studies. Patient. Child at the age of 5 years and 8 months with severe hepatomegaly, nephromegal…