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Molecular Medicine
Found: 348
Introduction. The interest in neutrophil extracellular traps (NETs) in various conditions, including pregnancy complications was increased over the last decade. Accompanied by gestational diabetes mellitus (GDM) hyperglycemia contributes to neutrophil’s activa…
Introduction. In present, the medical community continues to study the impact of coronavirus infection on various organs and systems of the body. Infection with the SARS-CoV-2 virus causes multifaceted pathological processes and, among other things, affects th…
Introduction. In clinical experiments with various pathologies leading to the activation of POL, it was found that one of the most important areas of correction of oxidative stress is the use of drugs with the properties of antioxidants and antihypoxants [6, 7…
Introduction. The study of the molecular mechanisms of skin aging is one of the key problems of dermatocosmetology. Inflamaging is a chronic low–level inflammation that occurs with age. This condition is characterized by a change in the expression of proteins …
Introduction. Chronic lymphocytic leukemia (CLL) is the most common leukemia type in adults. CLL is characterized by significant changes in the patient's genome, including both various mutations and epigenetic changes. These changes currently play an important…
Introduction. Angiogenesis regulators are of particular interest as new serum markers in cancer patients, since they reflect the intensity of tumor growth and metastasis. Currently, many works are dedicated to the study of vascular endothelial growth factor (V…
The development of metastases even long after treatment is one of the most important problems of medicine. There are mechanisms helping cancer cells to survive at various steps of metastasis. The ability of cancer cells to turn into dormant state characterizin…
Introduction. Many chemical compounds affect brain neurons differently than other cell populations. This is provided by the protective potential of the blood-brain barrier (BBB). One of the compounds capable of passing through the BBB is bacterial lipopolysacc…
Introduction. As is known, changes in the nail, as an appendage of the skin, can be genetically determined, caused by injuries, diseases, medications or exposure to harmful substances. Installation of partial or complete dentures may be required for any form o…
Introduction. The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor that is highly expressed in healthy lungs and performs homeostatic function there. However, the exact mechanisms of development of these diseases remain unk…
Introduction. Hyperglycemia inducers, the «classic» diabetogens streptozotocin and alloxan have a pronounced effect and are therefore limited suitable for modeling mild hyperglycemia in an experiment. Tyloxapol (Triton WR1339) was chosen as an alternative agen…
Studies of post-radiation lesions of the pancreas after irradiation with charged particles (electrons, protons) are few, however, electron therapy is one of the promising methods in radiobiology and can be used to model post-radiation pancreatitis. The mechani…
Introduction. Alkaline phosphatase (ALP) is an enzyme from the class of hydrolases, widely present in human tissues and organs. Intestinal ALP is one of the enzyme isoforms that is expressed in the mucous membrane throughout the intestine and is a marker of in…
Introduction. Oxidative stress (OS) occurs in various pathological processes, and acting as a nonspecific link in their pathogenesis. Less is known about its physiological role. The aim of study. Analysis of the results of world literature data and our own res…
Introduction. Thyroid disease is currently the most common among endocrine pathology. Hyperproduction of thyroid hormones is accompanied by stimulation of humoral reactions, contributing to the development of immune-mediated pathology under certain conditions,…
Introduction. Immobilization stress leads to the intensification of free-radical reactions leading to the destruction of sialoglycoproteins of the gastroduodenal zone. The aim of the study. To evaluate the features of the metabolism of sialoglycoproteins in th…
Introduction. Activation of the pro-inflammatory phenotype of microglia may be one of the causes of chronic neuroinflammation and, as a result, can lead to pathological conditions of the brain. The use of neurotrophic factors, such as FGF2, may become one of t…
Introduction. Lung cancer occupies a leading position in the structure of mortality from cancer. Chronic inflammation characteristic of tuberculosis increases the risk of lung cancer. Currently, more and more information is emerging confirming the cause-and-ef…
Introduction. Despite numerous studies in the field of neurodegenerative diseases, the exact mechanisms of these processes have not yet been identified. The purpose of this review is to analyze the methodological approaches necessary to revise the traditional …
The computational study of 3D-model hyaluronidase interaction with shortchain glycosaminoglycan ligands had performed demonstrating the diversity and significance of their reaction on enzyme structure. The purpose of this review was evolution of limiting enzym…