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Molecular Medicine
Found: 59
Introduction. Currently, in the pathogenesis of various diseases have been intensively studied the structure and function of innate immune receptors, a special role played by a Toll-like receptors (TLR). In the recent literature there are no comprehensive stud…
Objective. To study the distribution of PTPN22, TNFAIP3, CTLA4, TNFA, IL-6, IL-6R, IL-10, MCP-1, ICAM1 alleles and genotypes in early rheumatoid arthritis (eRA) patients and controls, and assess their value as potential molecular-genetic markers of predisposit…
Introduction. Cytochrome P-450 2C19 is the main isoenzyme responsible for the metabolism of proton pump inhibitors, the main group of drugs for treating stomach and duodenal ulcer. There are genetic differences that affect the activity of this enzyme: there ar…
Antipsychotics are the main medication for schizophrenia treatment. Recently the wideused group of them became second-generation antipsychotics (SGA). Due to that, problem of metabolic disturbances as side effect of SGA is more actually. The development of pha…
Introduction. Most cases of gastric cancer (GC) occur sporadically. Until recently, diffuse hereditary gastric cancer associated with the CDH1 gene mutations was considered the only hereditary form (about 1–3% of all tumors of the stomach). However, a signific…
Introduction. There were examined 195 patients with chronic сerebrovasсular pathology and 149 healthy residents of the Zabaykalsky region. The aim of the study. Detection of genetic polymorphism in cytokines IL4-589С>T, IL10-1082G>A, IL10-819C>T, IL10-592C>A, …
Gastric cancer (GC) arises through a multistep process characterized by the progressive accumulation of molecular alterations of tumor cells that is involving genetic and epigenetic mechanisms. GC is a very complex and heterogeneous disease, and although much …
Introduction. Ischemic stroke (IS) is a multifactorial disease, resulting from a complex interaction of genetic and environmental factors. Individual cause of the disease, multiple factors and symptoms require advanced mathematical methods of predicting IS ris…
Introduction. Although the interrelationship between disorders of the skeletal system with chronic gastroduodenitis (HGD) and infection with Helicobacter pylori (HP) currently has been well-studied in the literature practically there are no data reflecting the…
Introduction. Pharmacogenetic testing allows of increasing efficacy of anticoagulation therapy, reducing time required for adjusting therapeutic dose, and considerably reducing number of complications. The aim of the study. To investigate the dependence of the…
Introduction. Thymidylate synthase (TS) is a key enzyme in nucleotide biosynthesis and is the main intracellular target of 5-FU. We investigated the clinical and prognostic importance of TYMS gene 5' (TSR2/TSR3 and G>C) and 3' (del 6) untranslated region polym…
The development of allergic reactions to beta-lactam antibiotics is largely determined by genetic factors. In this work, to study the association of gene polymorphisms IL-4Rα (rs1801275) with the development of immediate hypersensitivity reactions (RGNT) to be…
Aim. To study a method of risk assessment neovascular age-related macular degeneration (AMD) with the genetic and clinical risk factors. Methods. The study included 255 patients with neovascular AMD (NVAMD) and 119 subjects in control group. Diagnosis and stag…
The article presents results of a comparison of clinical, genealogical and molecular genetic data of the study of the role of gene polymorphisms of renin - angiotensin system (REN (G83A), AGT (M235T), AGTR1 (A1166C)) in children with hypertension, with taking …
Formation of an effective strategy for managing patients after implantation of an artificial heart valve (АНV), in order to prevent thrombotic complications is an important problem in cardiology. The use of indirect anticoagulants, including warfarin reduces t…
Early diagnosis of ovarian cancer (OC) remains to be the actual problem in modern oncology due to the high mortality rate, asymptomatic course of the disease in the early stages and its aggressiveness. The aim was to study the genetic polymorphism of pathogene…
Ethiology and pathogenesis of bone tumors presenting a rare group of oncological diseases, are not fully understood. We have studied 6 single nucleotide polymorphisms rs7921 (GH1), rs7956547(IGF1), rs3761243(GNRH2), rs11737764(FGF2), rs6599400(FGFR3), rs169091…
In the current study the association of the endothelial nitric oxide synthase (NOS3) gene G894T and VNTR polymorphisms with the risk of miscarriage in ethnically homogeneous population has been investigated. The frequency of A/B VNTR genotype was revealed to p…
Introduction. Currently, scientists are paying increasing attention to the genetic condition of various pathologies. According to recent studies, cytokines play an essential role in the immune response in various pathological processes. The detection of geneti…