This website is intended for professionals in medicine and healthcare. By selecting “Confirm”, I declare that I am a member of this professional audience. I also agree to the publisher’s rules for using its information resource. Publisher’s resource rules (Russian)
Molecular Medicine
Found: 65
The data concerning the changes of expression and posttranslational modification of the human protein under the influence of the external and internal irradiation in vivo and in vitro are presented in this review. The investigation of protein expression and po…
The role of key adipokines (leptin, adiponectin, resistin, visfatin, apelin, omentin) had been assessed as important factors for perinatal complications in mother with disorders of carbohydrate metabolism. The survey based on the analysis of literature data. H…
Introduction. Penicillins and macrolides are applied for the treatment of both diphtheria carriers, in the comprehensive therapy of separate forms of diphtheria, and patients with invasive diseases caused by nontoxigenic C. diphtheriae. In the 1990s there was …
Aim is to evaluate distribution and clinical significance of gene CYP2C19 polymorfism in ST-segment elevation myocardial infarction (STEMI) patients. Materials and methods. A total of 159 patients were encluded in this study. All of them underwent primary PCI.…
Introduction. Determination of the role of genetic markers in the formation of individual susceptibility to the effects of harmful chemicals both opens up new possibilities for assessing the risk of occupational and production-related diseases and address prev…
Introduction. Russian population of Mycobacterium tuberculosis includes both highly virulent and less virulent strains; the Ural genotype makes an example of the latters. The aim of study was investigation of the most significant synonymous and non-synonymous …
Staphylococcus aureus – the pathogenic microorganism that can cause as well hospital as community-acquired diseases. The emergence and subsequent spread of strains resistant to many antimicrobial agents, and, above all, methicillin-hospital strains (HA-MRSA) a…
Introduction. Oxidative processes in the pathogenesis of chronic cardiovascular diseases play a key role. Oxidative stress causes the damage of many cellular components, including lipids and proteins. Oxidative modification of low-density lipoprotein triggers …
The main purpose of the treatment of bronchial asthma is achievement and maintenance of the control over the symptoms of disease at optimal level. For this purpose in terms of basic therapy there is used inhalation of as glucocorticosteroids as well systemic g…
The review highlights the problem of the influence of the genetic characteristics of patients in the dosage of anticoagulant drugs, the main adverse reaction of taking of which is the internal bleeding. Therapy with anticoagulant drugs is characterized by a wi…
MicroRNAs (miRNAs) – small non-coding RNAs targeting multiple mRNAs – are posttranscriptional regulators of gene expression involved in carcinogenesis, metastasis, and invasion. MiRNAs expression is altered in various human tumors including ovarian cancer. Ana…
Introduction. The phenomenon of drug resistance of Mycobacterium tuberculosis complex is extremely complicated. The determination of the genetic changes is not always able to explain reasons of this effect clearly. The aim of the study. Molecular genetic analy…
The key role in the achievement of the main goals of personalized medicine in oncology i.e. treatment choice according to patient’s individual characteristics and biological properties of the tumor belongs to tumor molecular markers characterizing the specific…
The formation of properties promoting malignant transformation begins before the appearance of tumor cells at the level of inflammatory and precancerous processes. The basis for these properties is genomic instability of tumor cells. Genetic instability manife…
Introduction. Disorders in anti-TB immunity may be formed at the stage of interaction between antigen-presenting cells and T-lymphocytes by means of cytokines and their receptors. The key cytokines of T-lymphocyte activation are interleukins (IL) of the IL12 f…
Introduction. Changes of steroid hormone receptors take an important place in the pathogenesis of endoemtriosis. Literature data about estrogen receptor-alpha (ERα) in this disease is contradictory. The aim of our study was to determine the expression of ERα a…
Introduction. According to the current understanding, oxidative stress plays a key role in the mechanisms of diabetes mellitus of types 1 and 2 emergence and development of its complications; formation of oxidative stress is accompanied by defective uptake of …
Genetically determined diversity in the activity of enzymes regulating the biotransformation of drugs and xenobiotics - cytochrome P450 (CYP) is one of the main causes of interindividual differences in the response of pharmacotherapy. The objective of this rev…
Abstract: This review summarizes the results of studies devoted to identification the dominant mechanisms of formation and persistence of inflammation in severe asthma. According to the latest research, the most likely causal factors and molecules that underli…
The article reviews modern data on the participation of signaling molecules in the pathogenesis of obesity. This review provides the detailed description of the functional morphology of adipose tissue as the major endocrine and immune organ. The imbalance in p…