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Molecular Medicine
Found: 63
Introduction. The pathological state of hypoxia of the body occurs with an inadequate supply of tissues and organs with oxygen or with a violation of its utilization in the process of biological oxidation. Ethylmethylhydroxypyridine has a multi-component mecha…
Introduction. Revealing the relationship between the severity of oxidative stress and the activity of cathepsins in tissues (plasma and blood cells) readily available for the diagnosis of Alzheimer’s disease can be useful for understanding the pathogenesis of …
Introduction. New directions of the modern cell biology are the development of methods for reprogramming stem cells into differentiated ones and reverse reprogramming of differentiated cells into stem cells. Transient processes in cells from the one stable sta…
Introduction. Neuroglia plays an important role in maintaining the stable functioning of the CNS. Of particular importance are neuroglial cells in the organization of the immune system of the brain, activating both with physical, physiological damage, and with…
There are presented data about rejuvenating mesencephalic astrocyte-derived neurotrophic factor (MANF) and its physiological functions. This is a new neurotrophic factor, produced by the mesencephalic astrocytes and it is different from other factors by its ac…
Schizophrenia is a severe psychiatric disorder with etiology not clearly determined yet. Scientists associate its development with various factors including excessive expression of some genes and unstable social environment. The World Health Organization estim…
This review article focuses on modern ideas about the role of neurotrophic factors (BDNF, NGF, NRG1, etc.) in the formation of the placenta and their impact on the development of the fetal nervous system in early ontogenesis. Data on the common effect of neuro…
Introduction. Prolapse of pelvic organs being extremely common in the female population, hence, it is important to search for factors of prolapse pathogenesis to identify markers of the optimal time for surgical intervention. The aim of the study is to investi…
The neuropeptide galanin (Gal) is widely distributed as well in central and peripheral nervous system, as in other organs and tissues of humans and animals. Its pleotropic effect is due to an activation or inhibition of galanin specific receptors – GalR1, GalR…
In acute focal ischemia of the heart and brain similar processes are developing despite the obvious differences in the structure, function, and blood supply of these organs. It was shown that under ischemic conditions synthesis stress induced proteins includin…
Introduction. Oxidative and nitrosative stresses are reported to be an important pathogenic factors of diabetes. Taking into account our previous findings that Noopept (N-phenyl-acetyl-L-prolyl-glycine ethyl ester) attenuates the hyperglycemia, decrease of inc…
The role of key adipokines (leptin, adiponectin, resistin, visfatin, apelin, omentin) had been assessed as important factors for perinatal complications in mother with disorders of carbohydrate metabolism. The survey based on the analysis of literature data. H…
A half century of studying the neurogenesis of the adult brain has produced much evidence for an endogenous conversion of neural stem cells. Yet the idea receives increasing criticism, in addition to the many positive comments. Does neurogenesis proceed at a r…
Introduction. Oxidative processes in the pathogenesis of chronic cardiovascular diseases play a key role. Oxidative stress causes the damage of many cellular components, including lipids and proteins. Oxidative modification of low-density lipoprotein triggers …
Introduction. Oxidative stress is developed as a result of imbalance between the generation of reactive oxygen species and activity of the antioxidant defence system. This in turn results in profound changes in metabolism of lipids, proteins and nucleic acids,…
Introduction. According to modern understanding, oxidative stress along with apoptosis dysregulation plays an important role in the pathogenetic mechanisms of tumor growth; formation of oxidative stress is accompanied by oxidative modification of cell protein …
Hepatocellular carcinoma (HCC) is the most prevalent form of malignant liver cancer characterized by late detection time and highly aggressiveness. The main risk factors for HCC development are chronic infections of hepatitis B and C viruses, cirrhosis, liver …
Introduction. Neuroendocrine cells are involved in multiple regulatory processes. In the article the attention is paid to the key signaling molecules that provide local interactions between neuroendocrine cells after radiation exposure. The aim of the study. T…
Introduction. Interactions of exposed on the tumor cell surface or circulating in the bloodstream molecules MICA with activating receptor NKG2D play an important role in the regulation of antitumor immune response. Accumulation of soluble MICA compromises NKG2…
Introduction. According to the current understanding, oxidative stress plays a key role in the mechanisms of diabetes mellitus of types 1 and 2 emergence and development of its complications; formation of oxidative stress is accompanied by defective uptake of …