Found: 81
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Kurbatova I.V., Dudanova O.P., Topchieva L.V., Larina A.A.
Introduction. The contribution of caspase-dependent apoptosis in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is not fully understood. One possible mechanism of hepatoprotective action of ursodeoxycholic acid (UDCA) is the suppression of apopto…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Trifonov N.I., Polyakova V.O., Medvedev D.S., Lin'kova N.S.
Introduction. Significance of chronic parodontitis is determined by not only of the degree of the prevalence rate, severity of the disease, but also by the low efficacy of the treatment and diagnosis at the early stage of disease. Nowadays there are not comple…
ОБЗОР2016
Korshunov D.A., Korshunova Z.V., Kondakova I.V.
Energy supply of cells can be provided through both an oxygen-dependent pathway of mitochondrial oxidative phosphorylation and oxygenindependent glycolysis. Oxidative phosphorylation in the synthesis of ATP is more efficient than in glycolysis, and respectivel…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016
Sin’kov V.V., Ogarkov O.B., Mokrousov I.V., Zhdanova S.N.
Introduction. Russian population of Mycobacterium tuberculosis includes both highly virulent and less virulent strains; the Ural genotype makes an example of the latters. The aim of study was investigation of the most significant synonymous and non-synonymous …
ОБЗОР2016
Komova E.G., Vavilin V.A., Ivanov M.K., Lyakhovich V.V.
The review highlights the problem of the influence of the genetic characteristics of patients in the dosage of anticoagulant drugs, the main adverse reaction of taking of which is the internal bleeding. Therapy with anticoagulant drugs is characterized by a wi…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016
Grigorian I. Yu., Linkova N. S., Kozlov K. L., Mursalov S.U.
Introduction. Endometritis and elder fertile age are the one of the main reason of infertility. Molecular methods of endometrial investigation have opened new perspectives in diagnostics and evaluation of the efficacy of the management of endometritis Objectiv…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015
Korotaeva A.A, Karpukhin A.V.
Genes encoding proteins of IAP (Inhibitor of apoptosis proteins) have increased expression in the cells of malignant tumors of different localizations. IAPs perform several functions related to the viability of cancer cells and their subsequent proliferation. …
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015
Soldatov V.M., Kozlov K.L., Linkova N.S.
Introduction. Age-assosiated endothelial changes are one of the reasons of the development of cardio-vascular pathology. Moreover, molecular mechanisms of human endothelium aging are investigated only slightly. Thus, the problem of pathogenesis of cardio-vascu…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015
Grigorian I.Ju., Polyakova V.O., Linkova N.S., Kukanova E.O., Paltseva E.M.
Introduction. Determination of the functional activity of the endometrium at the molecular-cellular level opens new perspectives for diagnosis and correction processes of accelerated aging and pathology of the female’s reproductive system. Objective – learning…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015
Paltsev M.A., Soldatov V.M., Kozlov K.L., Paltseva E.M., Linkova N.S., Polyakova V.O., Sedova E.V., Mursalov S.U., Kvetnoy I.M.
Introduction. Atherosclerosis proves to be age-dependent and social significant pathology. Knowledge of the role of signaling molecules in its development, and the elaboration on this basis molecular markers of restenosis after stenting of arteries remains to …
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015
Kozlov K.L., Soldatov V.M., Polyakova V.O., Linkova N.S., Drobintseva A.O., Medvedev D.S.
Introduction. Understanding of molecular and cellular mechanisms of vessels aging is the base of new approach creating of drugs for cardio-vascular pathology treatment. The goal of this work is the investigation of molecular and cellular mechanisms of vessels …
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015
Tsyganova I.V., Beliakov I.S., Anurova O.A., Mazurenko N.N.
Introduction. Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of GI tract, are characterized by KIT and PDGFRA activating mutations that are predictive factors. KIT and PDGFRA mutations are present in 85% of GISTs and are associated…
Research article2014
Chukhlovin A.B., Totolian Areg A.
The aim of our review article was to analyze different biological effects associated with functional allelic variants of certain genes upon the incidence and clinical course of uterine leiomyoma (UL) and some other hyperplastic uterine disorders. Based on a nu…
Research article2014
Ailamazyan E.K., Tolibova G.H., Petrosyan M.A., Tral' T.G., Serdiukov S.V.
Introduction. Endocrine factors are considered to be important in the etiology of spontaneous abortion. Aim of the study. Histological and immunohistochemical characterization of the expression of estrogen and progesterone receptors in the gravid endometrium d…
Research article2014
Khromov-Borisov N.N., Rubanovich A.V.
«Nothing in biomedicine makes sense except in the light of evolution». From this point of view, genetics of predispositions hasto answer two basic questions: 1. Is the natural genetic polymorphism identified with modern genomics proved to be the result of neut…
Research article2014
Saakyan S.V., Amiryan A.G., Tsygankov A.Yu., Loginov V.I., Burdennyy A.M.
Introduction.Uveal melanoma (UM) is one of the most frequent intraocular tumors. Mutations in new oncogenes GNAQ and GNA11 are found in more than 50% of UM. GNAQ gene and its homologue GNA11 are coding the alpha subunit of heterotrimeric G-protein with GTPase …
Research article2013
Romanov A.V., Chernov E.A., Edelstein M.V.
Staphylococcus aureus is a common human pathogen. In the past few decades, infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have become a global problem. MRSA is resistant to all β-lactam antibiotics, except anti-MRSA cephems, and is one…
Research article2012
Yabbarov N.G., Posypanova G.A., Vorontsov E.A.
Dendrimers are routinely synthesized as tuneable nanostructures that may be designed and regulated as a function of their size, shape, surface chemistry and interior void space. Dendrimers are hyperbranched polymers with unique physical and chemical properties…
ОБЗОР
Takha E.A., Shuralev E.A., Renaudineau Y., Arleevskaya M.I.
Introduction. Rheumatoid arthritis, like other multifactorial diseases, develops as a result of an inadequate response of a predisposed organism to environmental challenges. Material and methods. A review of the literature on the molecular mechanisms of the ef…
ОБЗОР
Chaulin A.M. P
Among a very significant number of possible variants of posttranslational modifications (PTM) affecting the contractile function of the myocardium, the most significant effect is exerted by posttranslational phosphorylation of protein components of the contrac…