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Molecular Medicine
Found: 120
Introduction. Human platelets maintain big reparative and regenerative potential. The biochemical content of platelet preparations seriously depends on methodic features. The aim of the study. To study cytokine content in different types of platelet soluble pr…
Introduction. The risk of bone tissue disturbance leading to a disability of diabetes mellitus patients brisks up the study of the mechanisms of diabetic osteopathy. The aim of the study. To study the indices of collagen exchange, the content of components of …
The review considers the role of hyaluronic acid (HA), primarily low-molecular-weight fractions of HA, in the regulation of the cell cycle of tumor cells. The formation of a pool of low-molecular weight HA molecules is due to the high activity of hyaluronidase…
Introduction. The main function of alpha-1 antitrypsin (A1AT) is inhibition of neutrophil elastinase and control over TNFα secretion. Anti-inflammatory properties of A1AT are manifested in leucocyte migration decrease and proliferation of T-lymphocytes through…
Introduction. To assess the pharmacokinetic indices of new drugs, it is necessary to develop analytical methods for determining their concentration in biological objects. Purpose of the study. Development and validation of HPLC-mass spectrometric methods for t…
The problems of longevity increase and its quality improvement are actual for the modern gerontology. So far it is necessary to complete tasks of early diagnostic and target prophylactic of the age-associated pathology. There are presented the data concerning …
Introduction. The investigation of biologic active substances, correcting the morphologic and functional characteristics of tissue changes, is an actual medicine task by the pathology therapy. Purpose of the study was the investigation of tetrapeptide AEDG eff…
Introduction. New directions of the modern cell biology are the development of methods for reprogramming stem cells into differentiated ones and reverse reprogramming of differentiated cells into stem cells. Transient processes in cells from the one stable sta…
Introduction. The scale of myocardial infarction plays a key role in the prognosis of the disease. Changes in contractile activity of myocardial tissue as a result of necrosis of cardiomyocytes is the decisive factor in this issue. The aim of the study. The pu…
Introduction. Psoriasis is a chronic inflammatory autoimmune disease with complex etiology including inheritable factors as well. Some scientists suggest psoriasis to be a systemic disease affecting not only skin. Thus, on the edge of dermatology and psychiatr…
There are presented data about rejuvenating mesencephalic astrocyte-derived neurotrophic factor (MANF) and its physiological functions. This is a new neurotrophic factor, produced by the mesencephalic astrocytes and it is different from other factors by its ac…
Introduction. Cancer stem cells (CSCs), which are less sensitive to chemotherapeutic drugs than other tumor cells, play a key role in the initiation and development of the tumor process. Maintenance of CSCs determines the risk of cancer recurrence. The aim of …
Introduction. In mammals, there are several populations of macrophages, developing from bone marrow progenitors and resident macrophages, developing from the embryonic precursors of the yolk. One of the reasons for the coexistence of several populations of mac…
Introduction. The brain injury induced during radiotherapy and chemotherapy is largely dependent on a disruption of neurogenesis in the subgranular zone of the dentate gyrus in the hippocampus as a result of the neural stem cells (NSCs) damage. The aim of the …
Introduction. Apolipoprotein-E (apoE), being one of the metabolically active apoproteins plays the important role in lipid metabolism. The aim of the study was to investigate the quantitative distribution of apoE between different lipoprotein classes in health…
Introduction. The search of molecular markers for early diagnostics, prognosis, and identification of new objects for molecular-targeted therapy of primary bone tumors remains one of the most important tasks despite the significant achievements in the treatmen…
Introduction. The incidence of infectious and inflammatory diseases, including sepsis, increases with the age, which is explained by the age-related decrease in the content of sex steroids. However, the features of the course of systemic inflammatory responses…
Cardiovascular diseases (CVD) are considered to be one of the leading causes of lethality in patients of older age groups. In the last decade, the issue of finding a material for effective non-invasive diagnosis of CVD has become urgent. The review considers t…
Purpose. To study pharmacokinetic parameters in studies of a comparative bioavailability in combination with the assessment of homeostatic mechanisms of the regulation on the example of calcium. Methods. There were studied pharmacokinetic parameters of calcium…
The aim of this work was to study the effect of methotrexate, glucocorticoids and nonsteroidal anti-inflammatory drugs on the plasma levels of nitric oxide metabolites, as well as the level of NOS2 gene transcripts in peripheral blood leukocytes (PBL) in rheum…