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Molecular Medicine
Found: 559
Introduction. In general, the physiological response of tissues to external stresses is not linear in accordance with Hooke's law. Biological tissues are known to exhibit a nonlinear relationship between stress and strain, although the origins of this nonlinea…
Introduction. Chronic heart failure is a multifactorial disease, an important role in the pathogenesis of which is played by disorders of the functions of mitochondria and energy metabolism in cardiomyocytes, as well as a significant contribution is made by ge…
Introduction. Heat shock proteins (HSPs) are a group of highly prospective compounds that can be used in various branches of clinical medicine, such as neurology, pharmacology and oncology. Studying the content of these proteins in various parts of the brain o…
Objective. To analyze the potential risks and technological limitations of using genome editing methods in neurodegenerative diseases, as well as to assess the prospects for their implementation in clinical practice. Material and methods. A systematic analysis…
Introduction. The pathogenesis of infection of the central nervous system (CNS) with SARS-CoV2 and nervourological complications are still poorly understood, as well as the link of viral infection with the risk and the course of gliomas. The aim. Evaluating of…
Introduction. Bronchial asthma is a heterogeneous disease involving different phenotypes. The allergic phenotype is the most studied model of asthma. Identification of causally significant allergens by determining allergen-specific IgE is the key to precision …
Objective. To analyze the current state of preclinical and clinical studies in genome editing for neurodegenerative diseases, evaluate its potential impact on clinical practice, and examine ethical aspects of these technologies’ application. Material and metho…
Introduction. The study of the molecular mechanisms of skin aging is one of the key problems of dermatocosmetology. Inflamaging is a chronic low–level inflammation that occurs with age. This condition is characterized by a change in the expression of proteins …
The purpose of this review is to analyze current advances in the field of genome editing, their application for the modeling and treatment of neurodegenerative diseases, as well as to discuss current limitations and prospects for overcoming barriers in clinica…
Introduction. Chronic lymphocytic leukemia (CLL) is the most common leukemia type in adults. CLL is characterized by significant changes in the patient's genome, including both various mutations and epigenetic changes. These changes currently play an important…
Introduction. Sarcoidosis is a systemic granulomatous disease of unknown origin. The study of its features and the development of new diagnostic and treatment methods are limited by the absence of generally accepted experimental models. The purpose of the revi…
Introduction. Immune checkpoint (IC) signaling pathways are involved in regulating the functions of T lymphocytes and NK cells, which play a key role in antitumor and antiviral control. The purpose of our study was to systematically analyze the information pre…
Introduction. Angiogenesis regulators are of particular interest as new serum markers in cancer patients, since they reflect the intensity of tumor growth and metastasis. Currently, many works are dedicated to the study of vascular endothelial growth factor (V…
Introduction. Artificial intelligence (AI) technologies are becoming crucial in clinical diagnostics due to their ability to process and interpret large volumes of data. The implementation of AI for biomarker analysis opens new opportunities in personalized me…
Introduction. Many chemical compounds affect brain neurons differently than other cell populations. This is provided by the protective potential of the blood-brain barrier (BBB). One of the compounds capable of passing through the BBB is bacterial lipopolysacc…
Background. During the last decades, data on potential cytoprotective effects of decarboxylated and deiodinated endogenous compounds – metabolites of thyroid hormones, constituting the thyronome, have been accumulated. The aim of this review is to systematize …
Introduction. An important pathogenetic link in systemic inflammation in ulcerative colitis (UC) is dysregulation of the immune response. The aim of the study: to study pathogenetic changes in the serum level of interleukin (IL)-4 during UC therapy. Methods. 6…
Introduction. Cancer cell drug resistance in melanoma is associated with evasion of apoptosis-induced stimuli. Assessing the level of expression of the BCL2 and SIRT1 genes in distant organs and the tumor node makes it possible to assess the resistance of mela…
Introduction. As is known, changes in the nail, as an appendage of the skin, can be genetically determined, caused by injuries, diseases, medications or exposure to harmful substances. Installation of partial or complete dentures may be required for any form o…
Dysfunction of the epidermal barrier plays an important role in the development of skin inflammatory processes. Pathological changes in the intracellular composition of keratinocytes are an integral part of the modern understanding of the pathogenesis of atopi…