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Molecular Medicine
Found: 196
Introduction. The effectiveness of antitumor immunity is determined by various mechanisms of recognition of tumor antigens, while the diversity of the repertoire of antigenic receptors is determined by V(D)J recombinations in maturing T and B cells. The aim of…
This review is devoted to summarizing the available data on the expression of long non-coding RNAs (lncRNAs) in lung cancer cells and tissues, their role in tumorigenesis, association with clinical and morphological characteristics and disease prognosis. The p…
The review is devoted to the analysis of modern ideas about the molecular mechanisms of the development of ferroptosis; the main conditions for the development of this type of cell death are described, and cell markers and targets for the induction of ferropto…
Introduction. Overcoming resistance to anticancer drugs in the treatment of malignant neoplasms is an urgent problem of recent decades. Unfortunately, there is no single mechanism for the development of resistance. Alterations that occur in a normal cell durin…
Relevance. The review is devoted to the issue of aging and the relationship of the molecular processes of aging with the pathology of the reproductive system The aim of the study was to review the current understanding of aging, the mechanisms and role in the …
Relevance: COVID-19 is the accepted name for an acute respiratory disease caused by the SARS-CoV-2 coronavirus. The suddenness, speed of spread, severity, and high lethality of COVID-19 have led many of the drugs used in the early stages of a pandemic to be ba…
The purpose of the study was to analyze literature data on the use of mesenchymal stem cells as a conservative treatment of osteoarthritis. Material and methods. Literature search was carried out using keywords: traumatology, orthopedics, mesenchymal stem cell…
Mesenchymal stem cells (MSCs) are attractive in various fields of regenerative medicine due to their therapeutic potential and complex unique properties. Basic stem cell research and the global COVID-19 pandemic have given impetus to the development of cell th…
The review is devoted to the analysis of modern ideas about the molecular mechanisms of tumor transformation in tuberculosis; signal molecules are described, which may be biomarkers and targets for optimizing personalized diagnosis and targeted therapy of the …
Introduction. Endometriosis is a chronic inflammatory estrogen-dependent disease characterized by the presence of endometrial tissue outside the uterine cavity. The pathogenesis of endometriosis is not fully determined. The relevance of its study is due to the…
Relevance: The review is devoted to the analyses of literature data on disorders of the immune system in COVID-19. Since some of the clinical symptoms of COVID-19 are consistent with those of autoimmune diseases, one of the fundamental questions about COVID-19…
The review is devoted to the analysis of modern ideas about the molecular mechanisms of the pathogenesis of sarcoidosis, it describes the signaling molecules involved in the development of sarcoidosis, which can be biomarkers and targets for optimizing persona…
The purpose of this review was to determine the role of physical activity as an integral component of environmental enrichment in the processes of neurogenesis in the rodent hippocampus. Material and methods. The full-text search has been carried out in the Me…
Cellular senescence is a reaction of cells to damage, which consists in a full stop of the cell cycle, changes of the signaling pathways and secretory activity associated with aging. Regardless the inducing factor, cellular aging of different types have a simi…
The senescence-associated secretory phenotype (SASP) is one of the causes of age-associated diseases, including atherosclerosis. The purpose of the review is to analyze data on the role of SASP cells of the cardiovascular system in the pathogenesis and pharmac…
The pathology of the respiratory organs is the leading one in the structure of the general human morbidity. Every year the number of diseases of the respiratory system increases, and the associated mortality increases in parallel. The study of the causes and m…
Tuberculosis remains one of the leading causes of death from infectious diseases in the world. According to WHO data, tuberculosis is diagnosed annually in more than 100 million people and causes 4.5 thousand deaths. Despite a steady decline in the main epidem…
Introduction. Rheumatoid arthritis, like other multifactorial diseases, develops as a result of an inadequate response of a predisposed organism to environmental challenges. Material and methods. A review of the literature on the molecular mechanisms of the ef…
Among a very significant number of possible variants of posttranslational modifications (PTM) affecting the contractile function of the myocardium, the most significant effect is exerted by posttranslational phosphorylation of protein components of the contrac…
Personalized therapy allows to reveal subtypes of diseases with similar symptoms but various molecular mechanisms of development. Different -omics (genomics, epigenomics, transcriptomics, proteomics ets) are used to divide the diseases into subtypes. Transcrip…