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Molecular Medicine
Found: 848
The most important event in the molecular biology of the last years is the discovery of the regulation of intracellular processes by micro RNAs – a product of complicated processing of precursor RNAs synthesized on nuclear genes, that are playing the key role …
Introduction. Activation of eNOS/sGC/cGMP-pathway is a common link in the development of angiogenic action of the majority of pro-angiogenic factors. In this regard, the chemical inhibition of NOS (Nitric Oxide Synthase) may cause a nonspecific angiostatic eff…
Prediction of clinical outcome of breast cancer (BC) is a multi-level process that includes the clinical and anatomical assessment both of the disease and the expression levels of proteins, DNA and RNA. This article discusses the application of traditional and…
The lecture considers common concepts of neuroendocrine tumors (NETs). Unlike the other tumors, NETs synthesize a variety of biologically active substances (hormones, peptides, amines), that being their main feature with multiple consequences leads to the deve…
Neuroendocrine tumors (NETs) constitute a heterogeneous group of relatively rare neoplasms, incidence of which has increased in the last decades. These tumors are composed of cells with a neuroendocrine phenotype and may occur in any organ, but are most often …
Among oncology diseases the primary bone tumors make up to 0,7–2,0% of all malignancies. The peak of morbidity caused by bone tumors falls on the age of person’s social activity. Bone tumors are one of the most aggressive among malignant human tumors. That’s w…
Gastric cancer (GC) arises through a multistep process characterized by the progressive accumulation of molecular alterations of tumor cells that is involving genetic and epigenetic mechanisms. GC is a very complex and heterogeneous disease, and although much …
Introduction. DNA methylation is a key epigenetic modification providing the regulation of human genome activity in ontogenesis. DNA methylation patterns were described in the chromosomes from adult lymphocytes. DNA methylation patterns of the chromosomes from…
Introduction. The study of growth factors in tissues of various kinds of nevi alongside with the skin melanoma can provide valuable information about the pathogenesis of the latter, determine the factors of early diagnostics of melanoma, as well as outline the…
Introduction. There is observed an incidence rate of irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD). The aim of the study. The study of the quantitative density of mast cells of the colon; enterochromaffin cells secreting serotonin, melat…
Introduction. Tissue barriers are the essential part of the compartmentalization in different organs. Tight junctions play a key role in paracellular transport. The selective permeability of tight junctions depends on expression of the claudin family of tight …
Introduction. According to inflammatory theory of atherosclerosis the immune damage of arteries with an autoimmune component – is the main link of its pathogenesis. The imbalance of cytokines production influences on course and prognosis of atherosclerosis. As…
Introduction. Ischemic stroke (IS) is a multifactorial disease, resulting from a complex interaction of genetic and environmental factors. Individual cause of the disease, multiple factors and symptoms require advanced mathematical methods of predicting IS ris…
Introduction. Although the interrelationship between disorders of the skeletal system with chronic gastroduodenitis (HGD) and infection with Helicobacter pylori (HP) currently has been well-studied in the literature practically there are no data reflecting the…
Introduction. The one of the most important problems of the modern regenerative medicine is incomplete understanding of the influence of mesenchymal stem cells (MSCs) on the growth of malignant neoplasms. Aim of the study. Analysis of the allogeneic MSCs’ effe…
Introduction. Colorectal cancer (CRC) often metastasizes even if the tumor is small in size that is the main cause of death. Complex process of epithelial-mesenchymal transition (EMT) is required for dissemination of tumor cells. EMT leads to the transformatio…
Aim. Lynch Syndrome, which is caused by a defect in one of the mismatch repair (MMR) genes, is the most common among all hereditary colorectal cancer syndromes. Patients with Lynch syndrome in different populations are inherent in both genetic and clinical fea…
Introduction. Pharmacogenetic testing allows of increasing efficacy of anticoagulation therapy, reducing time required for adjusting therapeutic dose, and considerably reducing number of complications. The aim of the study. To investigate the dependence of the…
Introduction. Russian drug Ribonucleate sodium (mixture of yeast ssRNA and dsRNA) possesses of the wide spectrum of antiviral and immunomodulation actions, it improves the efficacy of inactivated vaccines in experimental animals. It can activate IFN-system gen…
Since the middle of the last century, discoveries in the area of molecular biology and physiology somehow led to the revolution in the view of the function and role of the adipocyte in the human body. To date, there have been known and studied more than four a…