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Molecular Medicine
Found: 841
Neuroendocrine tumors (NETs) constitute a heterogeneous group of relatively rare neoplasms, incidence of which has increased in the last decades. These tumors are composed of cells with a neuroendocrine phenotype and may occur in any organ, but are most often …
Among oncology diseases the primary bone tumors make up to 0,7–2,0% of all malignancies. The peak of morbidity caused by bone tumors falls on the age of person’s social activity. Bone tumors are one of the most aggressive among malignant human tumors. That’s w…
Gastric cancer (GC) arises through a multistep process characterized by the progressive accumulation of molecular alterations of tumor cells that is involving genetic and epigenetic mechanisms. GC is a very complex and heterogeneous disease, and although much …
Introduction. DNA methylation is a key epigenetic modification providing the regulation of human genome activity in ontogenesis. DNA methylation patterns were described in the chromosomes from adult lymphocytes. DNA methylation patterns of the chromosomes from…
Introduction. The study of growth factors in tissues of various kinds of nevi alongside with the skin melanoma can provide valuable information about the pathogenesis of the latter, determine the factors of early diagnostics of melanoma, as well as outline the…
Introduction. There is observed an incidence rate of irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD). The aim of the study. The study of the quantitative density of mast cells of the colon; enterochromaffin cells secreting serotonin, melat…
Introduction. Tissue barriers are the essential part of the compartmentalization in different organs. Tight junctions play a key role in paracellular transport. The selective permeability of tight junctions depends on expression of the claudin family of tight …
Introduction. According to inflammatory theory of atherosclerosis the immune damage of arteries with an autoimmune component – is the main link of its pathogenesis. The imbalance of cytokines production influences on course and prognosis of atherosclerosis. As…
Introduction. Ischemic stroke (IS) is a multifactorial disease, resulting from a complex interaction of genetic and environmental factors. Individual cause of the disease, multiple factors and symptoms require advanced mathematical methods of predicting IS ris…
Introduction. Although the interrelationship between disorders of the skeletal system with chronic gastroduodenitis (HGD) and infection with Helicobacter pylori (HP) currently has been well-studied in the literature practically there are no data reflecting the…
Introduction. The one of the most important problems of the modern regenerative medicine is incomplete understanding of the influence of mesenchymal stem cells (MSCs) on the growth of malignant neoplasms. Aim of the study. Analysis of the allogeneic MSCs’ effe…
Introduction. Colorectal cancer (CRC) often metastasizes even if the tumor is small in size that is the main cause of death. Complex process of epithelial-mesenchymal transition (EMT) is required for dissemination of tumor cells. EMT leads to the transformatio…
Aim. Lynch Syndrome, which is caused by a defect in one of the mismatch repair (MMR) genes, is the most common among all hereditary colorectal cancer syndromes. Patients with Lynch syndrome in different populations are inherent in both genetic and clinical fea…
Introduction. Pharmacogenetic testing allows of increasing efficacy of anticoagulation therapy, reducing time required for adjusting therapeutic dose, and considerably reducing number of complications. The aim of the study. To investigate the dependence of the…
Introduction. Russian drug Ribonucleate sodium (mixture of yeast ssRNA and dsRNA) possesses of the wide spectrum of antiviral and immunomodulation actions, it improves the efficacy of inactivated vaccines in experimental animals. It can activate IFN-system gen…
Since the middle of the last century, discoveries in the area of molecular biology and physiology somehow led to the revolution in the view of the function and role of the adipocyte in the human body. To date, there have been known and studied more than four a…
Breast cancer (BC) occupies the first place in morbidity and mortality rate in females in developed counties. From the point of view of biology BC proves to be the heterogenic disease, caused by genetic variability. It determines the phenotype of tumor and sen…
Introduction. To date, the mechanisms underlying the majority of cardiac arrhythmias are unclear. The disturbance of sympathetic innervation of the heart may be as well the cause of atrial fibrillation (AF), as the reason of myocardial dysfunction of the left …
Introduction. In the structure of gynecological diseases endometriosis ranks third after inflammatory disease and uterine fibroids. Despite intensive study of the pathogenesis of endometriosis, many of the key moments remained to be unclear. In this regard, it…
Introduction. Despite the fact that portal hypertensive gastropathy (PHG) developing in patients with portal hypertension (PH) is a serious clinical problem, its pathogenesis remains to be poorly studied. The aim of our research was to study the proapoptotic p…