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Molecular Medicine
Found: 848
Breast cancer (BC) occupies the first place in morbidity and mortality rate in females in developed counties. From the point of view of biology BC proves to be the heterogenic disease, caused by genetic variability. It determines the phenotype of tumor and sen…
Introduction. To date, the mechanisms underlying the majority of cardiac arrhythmias are unclear. The disturbance of sympathetic innervation of the heart may be as well the cause of atrial fibrillation (AF), as the reason of myocardial dysfunction of the left …
Introduction. In the structure of gynecological diseases endometriosis ranks third after inflammatory disease and uterine fibroids. Despite intensive study of the pathogenesis of endometriosis, many of the key moments remained to be unclear. In this regard, it…
Introduction. Despite the fact that portal hypertensive gastropathy (PHG) developing in patients with portal hypertension (PH) is a serious clinical problem, its pathogenesis remains to be poorly studied. The aim of our research was to study the proapoptotic p…
Introduction. Chronic bronchitis is one of the socially significant diseases. Accordingly, a search of the new more effective and safe bronchoprotective drugs is the one of aims of molecular medicine. The aim of the study. The goal of our research was the inve…
The paper is devoted to the history of the discovery of a new class of signaling molecules – kisspeptins and analysis of current ideas on their biological role. KISS1 gene was first described in 1996 as a gene which prevents metastasis of tumor cells. In the f…
Introduction. Galectin-1 binds to cell surface glycoprotein and participates in cooperation of immune cells. It is supposed that the CD4+- lymphocytes can be target for immunosuppressive activity of galectin-1. However, there is no sufficient information about…
Introduction. Disorders in anti-TB immunity may be formed at the stage of interaction between antigen-presenting cells and T-lymphocytes by means of cytokines and their receptors. The key cytokines of T-lymphocyte activation are interleukins (IL) of the IL12 f…
Introduction. One of the important tasks of hepatology is the prognosis of viral hepatitides. The prognosis is based on the analysis of genetic determination of the functioning of antiviral immunity, particularly, of the cytokine system. The aim of the study w…
Introduction. Skin melanoma is referred to hormone-dependent tumors, the mechanism of influence of endocrine factors on pathogenesis of the tumor, however, has not been determined so far The aim of the study. The studying of the level of steroid hormones, prol…
Introduction. One of the most prospective approaches in therapy of deep skin burns is the development of artificial dermal equivalents with a potential to provide efficient scaffolding for dermis reconstruction and re-epithelisation. The choice of material for…
Introduction. Epigenetic changes caused by methylation in promoter CpG-islands are a fine and dynamic mechanism of gene expression regulation in tumors. Increased and decreased expression and alterations in the methylation status of the gene are considered to …
Introduction. Legg–Calve–Perthes disease or osteonecrosis of the femoral head with the occurrence rate of 25–30% takes the leading place among diseases of the musculoskeletal system in children. Nowadays there are some diagnostic methods to determine the stage…
Introduction. Neuroendocrine cells are involved in multiple regulatory processes. In the article the attention is paid to the key signaling molecules that provide local interactions between neuroendocrine cells after radiation exposure. The aim of the study. T…
Introduction. Currently, the study of molecular and cellular bases for the development of frailty is an actual scientific problem. The aim of the article is to study the morphofunctional and cytochemical characteristics of erythrocytes in frailty patients. Met…
Introduction. Modulation of cellular adhesion of the retinal pigment epithelium (RPE) is a highly promising therapeutic approach for different eye diseases. As inflammation plays the crucial role in ocular diseases the impact of prostaglandins and proteases on…
Introduction. In recent years among non-drug methods of treatment and rehabilitation of patients of elderly and senile age is a promising application of low-intensity millimeter waves as an important reserve of increasing the effectiveness of the complex thera…
Introduction. Development of rapid and accurate tests is of priority in microbiological diagnostics, including diagnostics of urogenital infections. The aim of the study. The study aimed to develop and evaluate a diagnostic microchip panel based on real-time P…
Introduction. Preeclampsia is one of the most frequent complications of pregnancy. Disease is based on the pathology of the vascular system of a pregnant woman. One of the candidate genes of preeclampsia is a gene encoding a protein receptor type 2A to activin…
Introduction. Changes of steroid hormone receptors take an important place in the pathogenesis of endoemtriosis. Literature data about estrogen receptor-alpha (ERα) in this disease is contradictory. The aim of our study was to determine the expression of ERα a…