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Molecular Medicine
Found: 277
Relevance. The review is devoted to the analysis of modern ideas about the functional role of connexins in intercellular interactions, their participation in maintaining cellular and tissue homeostasis and in the pathogenesis of diseases of the respiratory sys…
Introduction. There is a steady increase in the incidence of type 2 diabetes worldwide. One of the most formidable complications of this pathology is the development of diabetic foot syndrome, which is accompanied by up to 50% of cases of high amputations, dis…
Introduction. There is take place increasing in the incidence of obesity among children and adolescents in the world. However, until now there are not exist clear views about mechanisms of that phenomenon. The aim of study. The purpose of that work is comparat…
Introduction. Iron is one of the main elements for the vital activity of the body. Iron deficiency leads to the development of iron deficiency anemia, one of the most common diseases in the Russian Federation; excess iron induces oxidative stress. In this way,…
Relevance: COVID-19 is the accepted name for an acute respiratory disease caused by the SARS-CoV-2 coronavirus. The suddenness, speed of spread, severity, and high lethality of COVID-19 have led many of the drugs used in the early stages of a pandemic to be ba…
One of the most important tasks of modern medicine is to recognize diseases at the preclinical stage, as well as to assess their development risks and their possible prevention. This dictates the need to use new, modern technologies aimed at the early detectio…
Introduction. The epidemiological process in tuberculosis is negatively affected by the HIV epidemic, the identification of vulnerable groups in relation to the unfavorable course of tuberculosis in combination with HIV infection will improve approaches to tre…
The article describes the results of an experimental study of tissue-engineering constructions based on lactic acid – poly-L,L-lactide, containing allogeneic cells of various tissue origin. Aim: to show experimentally the possibility of using an allogeneic tis…
Introduction. A transition of proliferating cancer cells to a G0 phase of a cell cycle considered to be implicated in cancer cell drug resistance. The aim of the study. A separation of G0-positive melanoma B16 cells fraction that correspond to resting followed…
Aim of investigation. The development of a non-invasive express method for assessing the state of the hemostasis system during transplantation of large joints is an urgent task, since it allows you to adjust the appointment of anticoagulant therapy and prevent…
Mesenchymal stem cells (MSCs) are attractive in various fields of regenerative medicine due to their therapeutic potential and complex unique properties. Basic stem cell research and the global COVID-19 pandemic have given impetus to the development of cell th…
Introduction. Endometriosis is a chronic inflammatory estrogen-dependent disease characterized by the presence of endometrial tissue outside the uterine cavity. The pathogenesis of endometriosis is not fully determined. The relevance of its study is due to the…
The reasons for the low efficiency of the α1A-blockers using in the scheme of lithokinetic therapy (LCT) remain unclear. The aim of the study was to evaluate the activity of the purinergic P2X1 receptor in the blockade of the α1A-adrenergic receptor during LCT…
The majority of IgE binds with Fcε mast cells receptors. Repeated contacts between allergen and specific IgE on the surface of mast cells result in Fcε-receptors cross-linking, degranulation and release of inflammation mediators such as histamine, proteases, c…
The incidence of Alzheimer’s disease (AD) in people older 80 years old is 52%. Consequently, the predictive diagnostic of this neurodegenerative disease in long-liver is the actual goal of molecular medicine and gerontology. The aim of the research is to compa…
Among a very significant number of possible variants of posttranslational modifications (PTM) affecting the contractile function of the myocardium, the most significant effect is exerted by posttranslational phosphorylation of protein components of the contrac…
Introduction. The worldwide trend towards green technologies has increased interest in the development and use of natural, highly-efficiency and inexpensive plant antioxidants to replace existing synthetic ones. Purpose of the study. study of the composition o…
The aim of the study was to study the effect of chemical immobilization of yeast cell wall glycoproteins on their ability to activate cytokine production by human peripheral blood cells. Methods. A comparative analysis of the immunomodulatory activity of yeast…
The aim is the comparative analysis of saliva concentration of sirtuins, in middle age and elderly people without cardiovascular pathology (CP) and with coronary heart disease (CHD). Methods. Saliva was obtained from healthy donors (73 persons without CP, «nor…
Introduction. Mitochondria are one of the most important cellular organelles that provide cells with energy, take part in cellular renewal and the implementation of endogenous mechanisms of cellular immunity. The study of the structural and functional organiza…