This website is intended for professionals in medicine and healthcare. By selecting “Confirm”, I declare that I am a member of this professional audience. I also agree to the publisher’s rules for using its information resource. Publisher’s resource rules (Russian)
Molecular Medicine
Found: 120
Introduction. Glycine is well-known to have a positive effect in the treatment of patients suffered from an ischemic stroke. Vasodilatation is one of the main parts of the action of this amino acid at the molecular level. Simultaneously, the increase of oxygen…
Modern methods of treatment of Parkinson's disease (PD) remain to be unsuccessful in cessation of the progression of neurodegenerative processes in the brain. The role of certain genes is proven by the etiology of PD, 10–15% of cases represent a monogenic dise…
Introduction. The gain of elderly persons in the population of industrial countries provides a high actuality to investigations of pathogenesis of calcific aortic valve stenosis (CAVS). The aim of the study. To specify the quality and quantity pattern of colla…
Purpose an experimental evaluation of the effectiveness of new hydrogels based on hyaluronic acid and chitosan succinate as an agent of mitomycin C (MMC) for glaucoma surgery. Material and methods. Synthesis of hydrogel drainage (HD): The required amount of MM…
In the presented review a new potential risk factor for atherosclerosis and cardiovascular disease such as microflora of the human gastrointestinal tract is considered. The modern concept of lipid metabolism and its effects on human health outlining the basic …
The role of key adipokines (leptin, adiponectin, resistin, visfatin, apelin, omentin) had been assessed as important factors for perinatal complications in mother with disorders of carbohydrate metabolism. The survey based on the analysis of literature data. H…
Introduction. Ulcerative colitis is a chronic inflammatory disease. Misbalance in innate and adaptive immunity including cytokines plays a significant role in its pathogenesis. Objective. To determine levels of cytokine TGFβ1, 2, 3, and IL6 in blood of patient…
Introduction. Oxidative processes in the pathogenesis of chronic cardiovascular diseases play a key role. Oxidative stress causes the damage of many cellular components, including lipids and proteins. Oxidative modification of low-density lipoprotein triggers …
Introduction. Ambient air pollution is important worldwide problem. Numerous studies have found associations between air pollution and respiratory diseases, cardiovascular diseases, diabetes, and infant mortality. Children are more susceptible to the air pollu…
Introduction. Mediator release from mast cells or basophils is the key event in many acute allergic and inflammatory processes. Rat basophilic leukemia cell line RBL-2H3 cells is widely used as a model for studying mast cells degranulation. Aim of the study. T…
Introduction. RANK/RANKL/OPG ligand-receptor system is a key player in bone tissue homeostasis directly regulating osteoclast differentiation and osteolysis. Many pathologic processes imposed by impairments in bone remodeling including tumor growth and metasta…
Introduction. Nitric oxide is a well-known regulator of different metabolic processes in cells and tissues. Its effect is usually represented as a balanced combination of both mediator and toxic action and the mutual ranges of them are not simply identified. I…
Introduction. Insulin-like growth factors (IGF) signaling system plays a major role in the development and progression of various sarcomas and other solid tumors, and therefore its components are regarded as promising diagnostic and prognostic tumor markers an…
Introduction: Insulin-like growth factors (IGFs), insulin-like growth factor-I receptor (IGF-IR), IGR-binding proteins (IGFBPs) and IGBP proteases can play an important role in the development of metastases in ovarian cancer. The relationship between IGF syste…
Introduction. In interstitial lung diseases (ILD), characterized by inflammatory and fibrous processes, the intensification of angiogenesis also occurs. The aim of our research. Was the study of characteristics of expression angiogenic molecules (VEGF, ET1) in…
Introduction. According to modern understanding, oxidative stress along with apoptosis dysregulation plays an important role in the pathogenetic mechanisms of tumor growth; formation of oxidative stress is accompanied by oxidative modification of cell protein …
Introduction. Owing to the intensive development of neurosciences immunoassay methods have received a widespread use. These methods allow studying the functioning features of the nervous system in trauma at the molecular level . The purpose of the study. The p…
Introduction. There were examined 195 patients with chronic сerebrovasсular pathology and 149 healthy residents of the Zabaykalsky region. The aim of the study. Detection of genetic polymorphism in cytokines IL4-589С>T, IL10-1082G>A, IL10-819C>T, IL10-592C>A, …
Introduction. Amnesic shellfish poisoning is caused by consumption of seafoods contaminated with domoic acid (DA) and is accompanied by gastric colics, nausea, convulsions, hallucinations, loss of orientation and amnesia. As a preventive measure against these …
Breast cancer (BC) occupies the first place in morbidity and mortality rate in females in developed counties. From the point of view of biology BC proves to be the heterogenic disease, caused by genetic variability. It determines the phenotype of tumor and sen…