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Molecular Medicine
Found: 109
Introduction. Most cases of gastric cancer (GC) occur sporadically. Until recently, diffuse hereditary gastric cancer associated with the CDH1 gene mutations was considered the only hereditary form (about 1–3% of all tumors of the stomach). However, a signific…
Introduction. There were examined 195 patients with chronic сerebrovasсular pathology and 149 healthy residents of the Zabaykalsky region. The aim of the study. Detection of genetic polymorphism in cytokines IL4-589С>T, IL10-1082G>A, IL10-819C>T, IL10-592C>A, …
Gastric cancer (GC) arises through a multistep process characterized by the progressive accumulation of molecular alterations of tumor cells that is involving genetic and epigenetic mechanisms. GC is a very complex and heterogeneous disease, and although much …
Introduction. According to inflammatory theory of atherosclerosis the immune damage of arteries with an autoimmune component – is the main link of its pathogenesis. The imbalance of cytokines production influences on course and prognosis of atherosclerosis. As…
Introduction. Ischemic stroke (IS) is a multifactorial disease, resulting from a complex interaction of genetic and environmental factors. Individual cause of the disease, multiple factors and symptoms require advanced mathematical methods of predicting IS ris…
Introduction. Although the interrelationship between disorders of the skeletal system with chronic gastroduodenitis (HGD) and infection with Helicobacter pylori (HP) currently has been well-studied in the literature practically there are no data reflecting the…
Introduction. Pharmacogenetic testing allows of increasing efficacy of anticoagulation therapy, reducing time required for adjusting therapeutic dose, and considerably reducing number of complications. The aim of the study. To investigate the dependence of the…
Introduction. One of the important tasks of hepatology is the prognosis of viral hepatitides. The prognosis is based on the analysis of genetic determination of the functioning of antiviral immunity, particularly, of the cytokine system. The aim of the study w…
The aim of our review article was to analyze different biological effects associated with functional allelic variants of certain genes upon the incidence and clinical course of uterine leiomyoma (UL) and some other hyperplastic uterine disorders. Based on a nu…
Introduction. Thymidylate synthase (TS) is a key enzyme in nucleotide biosynthesis and is the main intracellular target of 5-FU. We investigated the clinical and prognostic importance of TYMS gene 5' (TSR2/TSR3 and G>C) and 3' (del 6) untranslated region polym…
Introduction. The COMT gene encodes for a protein involved in deactivation of genotoxic estrogen species, and the protein product encoded by the L (low activity) allele is 3–5-fold less active than its counterpart encoded by the H (high activity) allele. The a…
Introduction.The rs8175347 ((TA)5/6/7/8) in the UGT1A1 gene polymorphism is associated with the expression of UDP glucuronosyltransferase 1A1 enzyme. The low enzyme activity in patients with (TA)7 and (TA)8 alleles is associated with the risk of Gilbert syndro…
«Nothing in biomedicine makes sense except in the light of evolution». From this point of view, genetics of predispositions hasto answer two basic questions: 1. Is the natural genetic polymorphism identified with modern genomics proved to be the result of neut…
Introduction.Study of the influence of molecular and genetic predisposition to forecast neurorehabilitation patients with stroke is of great scientific and practical importance. The aim of the study.Determining the impact of allelic polymorphism Val66Met BDNF …
Introduction.Uveal melanoma (UM) is one of the most frequent intraocular tumors. Mutations in new oncogenes GNAQ and GNA11 are found in more than 50% of UM. GNAQ gene and its homologue GNA11 are coding the alpha subunit of heterotrimeric G-protein with GTPase …
Genetically determined diversity in the activity of enzymes regulating the biotransformation of drugs and xenobiotics - cytochrome P450 (CYP) is one of the main causes of interindividual differences in the response of pharmacotherapy. The objective of this rev…
The development of allergic reactions to beta-lactam antibiotics is largely determined by genetic factors. In this work, to study the association of gene polymorphisms IL-4Rα (rs1801275) with the development of immediate hypersensitivity reactions (RGNT) to be…
We have studied BDNF gene Val66Met polymorphism in patients with a high risk of mortality due to stroke or severe head injury. Genotype ValVal rate was higher than that of in the control group in the total sample of subjects (75,5% and 63,6%; χ2=4,63; df=1; p=…
Aim. To study a method of risk assessment neovascular age-related macular degeneration (AMD) with the genetic and clinical risk factors. Methods. The study included 255 patients with neovascular AMD (NVAMD) and 119 subjects in control group. Diagnosis and stag…
The results of the study of endothelin-1(Lys198Asn) polymorphism in Transbaikalia region in patients of russian and buryat nationality with peripheral vitreoretinal degeneration are presented. In patients the frequency of Asn-allele is higher than in healthy c…