This website is intended for professionals in medicine and healthcare. By selecting “Confirm”, I declare that I am a member of this professional audience. I also agree to the publisher’s rules for using its information resource. Publisher’s resource rules (Russian)
Molecular Medicine
Found: 202
Introduction. Myoma occupies a leading place in the structure of gynecological diseases, reduces the fertility rate and living standardsin females of reproductive age. In 85% cases myoma is combined with adenomyosis, which complicates the treatment and increas…
Introduction. Missed and spontaneous abortions are one of the most important causes of the reproductive loss. The aim of the study: to study specialties of mRNA expression of p53 and proteins of its signaling pathway in the decidual tissue at 6–10 weeks of ges…
Introduction. Uveal melanoma (UM) is a tumor of neuroectodermal origin developing from melanocytes of the uveal tract. The very common pathological characteristic of UM is its metastatic activity in liver, leading to the poor efficiency of the treatment. That`…
Introduction. A possible pathogenesis for Crohn’s disease (CD) involves the provocation of uncontrollable immune response by intestinal microbiota. Escherichia coli is regarded as a candidate for possible pathogen, since its content is increased in intestine o…
The headache is an important medical and social problem. Currently, genetics is the least-studied component of the pathogenesis of primary headaches. The most common forms of primary headache include migraine, tension type headache, cluster headache. This arti…
Parkinson’s disease (PD) is a progressive, age-related, neuronal disorder that affects as much as 1% of the persons over 65 years. According to forecasts of the World Health Organization over the world about 9 million people will suffer from PD by 2030. So PD …
The review considers the main trends of the new concept of individual health medicine, called the predictive preventive personalized participative medicine – P4 Medicine. Medico-biological and medico-social prerequisites for the development of personalized med…
Introduction. The physiological state of the skin vasculature is largely determined by the influence of environmental factors, including the alteration of the oxygen partial pressure. Obviously, the epidermis, as the surface layer of the skin, should play a ke…
Uveal melanoma (UM) is a rare, aggressive intraocular malignant tumor, leading to metastatic disease in more than 50% of patients. Cytogenetic and molecular studies have identified some genetic prognostic factors considered to be reliable to forecast the survi…
Introduction. Taken into account the literature data on the leading role of perceptual deficit in the pathogenesis of schizophrenia and the lack of experimental models of this impairment we proposed the novel test of instinctive aversion (TIA). The work was pe…
Introduction. Erysipelas is characterized by consistently high morbidity rate, pronounced tendency to recur, the frequent change of lymph circulation, formation of secondary elephantiasis and others symptoms. The prediction of the course of erysipelas is unres…
Introduction. The gain of elderly persons in the population of industrial countries provides a high actuality to investigations of pathogenesis of calcific aortic valve stenosis (CAVS). The aim of the study. To specify the quality and quantity pattern of colla…
Introduction. Insulin-like growth factor (IGF) signaling system plays a major role in development and progression of various malignant tumors including colorectal cancer (CRC), so far its components are considered as potential diagnostic and prognostic markers…
Introduction authors made an attempt to demonstrate the role of DNA-methylation in pathogenesis of uterine fibroids. The epigenetic aspects based on personal investigations and literary data have been reviewed. The research underlined a perspective of investig…
Introduction. The contribution of caspase-dependent apoptosis in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is not fully understood. One possible mechanism of hepatoprotective action of ursodeoxycholic acid (UDCA) is the suppression of apopto…
Introduction. Radiotherapy becomes a standard of combination treatment of the rectal cancer. That is why the development of its pathogenetical bases is very impotent. The aim of the study. The purpose of the study was to analyze molecular and morphological eff…
Introduction. Pathogenesis of infective endocarditis (IE) is not quite clear till now. In last years research of variants of the genes connected with pathogenesis of IE was performed. The aim. The investigation of IE association with gene single-nucleotide pol…
In the context of the continuing importance of the problem of tuberculosis there must be the selection both of priority areas to combat it, and priority category of patients. The most common form of TB among new cases is infiltrative and successful treatment o…
Abstract sources: PubMed, WINITI RAS, Embase, Web of Science, Cochrane database, Current Controlled Trials for information about associations of polymorphism of genes cytokines (IL6, TNFα, IL10, TGFβ) with atherosclerosis and its complications are analyzed. As…
Introduction. Glycogen storage disease (GSD) type Ib is caused by mutations in the SLC37A4 gene. The aim of the study. To verify the diagnosis by molecular genetic studies. Patient. Child at the age of 5 years and 8 months with severe hepatomegaly, nephromegal…