Found: 248
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Kurbatova I.V., Dudanova O.P., Topchieva L.V., Larina A.A.
Introduction. The contribution of caspase-dependent apoptosis in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is not fully understood. One possible mechanism of hepatoprotective action of ursodeoxycholic acid (UDCA) is the suppression of apopto…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Kit O.I., Gevorkyan Yu.A., Soldatkina N.V., Novikova I.A., Gusareva M.A., Kozhushko M.A.
Introduction. Radiotherapy becomes a standard of combination treatment of the rectal cancer. That is why the development of its pathogenetical bases is very impotent. The aim of the study. The purpose of the study was to analyze molecular and morphological eff…
ОБЗОР2017
Gurova Ya.V., Mordyk A.V.
In the context of the continuing importance of the problem of tuberculosis there must be the selection both of priority areas to combat it, and priority category of patients. The most common form of TB among new cases is infiltrative and successful treatment o…
ОБЗОР2017
Karaulov A.V., Turmova E.P., Markelova E.V., Silaev A.A.
Abstract sources: PubMed, WINITI RAS, Embase, Web of Science, Cochrane database, Current Controlled Trials for information about associations of polymorphism of genes cytokines (IL6, TNFα, IL10, TGFβ) with atherosclerosis and its complications are analyzed. As…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Surkov A.N., Baranov A.A., Namazova-Baranova L.S., Savostyanov K.V., Pushkov A.A., Zhurkova N.V., Kustova O.V., Potapov A.S., Movsisyan G.B., Gevorkyan A.K., Volynets G.V., Skvortsova T.A.
Introduction. Glycogen storage disease (GSD) type Ib is caused by mutations in the SLC37A4 gene. The aim of the study. To verify the diagnosis by molecular genetic studies. Patient. Child at the age of 5 years and 8 months with severe hepatomegaly, nephromegal…
ОБЗОР2017
Kit O.I., Vodolazhsky D.I., Timoshkina N.N.
The frequency of reported cases of melanoma and related mortality rates continue to increase worldwide. The study of the basic mechanisms of both the initiation and development of this highly aggressive tumour proves to be important for the identification of t…
ОБЗОР2017
A.V. Zaborovskiy, N.A. Pyataev, L.A. Tararina, K.G. Gurevich, I.V. Maev, I.S. Кrysanov, D.V. Yunina
At present, various antineoplastic agents are widely used to treat cancer. There are certain problems associated with their use, such as the inhibition of the pool of dividing cells, poor tolerance and efficiency. Targeted therapy also has several disadvantage…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Trifonov N.I., Polyakova V.O., Medvedev D.S., Lin'kova N.S.
Introduction. Significance of chronic parodontitis is determined by not only of the degree of the prevalence rate, severity of the disease, but also by the low efficacy of the treatment and diagnosis at the early stage of disease. Nowadays there are not comple…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Borisova O.Yu., Chagina I.A., Aleshkin V.A.
Introduction. Penicillins and macrolides are applied for the treatment of both diphtheria carriers, in the comprehensive therapy of separate forms of diphtheria, and patients with invasive diseases caused by nontoxigenic C. diphtheriae. In the 1990s there was …
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2017
Sytina E.V., Chikitkina Y.A., Tenchurin T.Kh., Paltsev M.A., Panteleyev A.A.
Introduction. Contracting deep scars are almost unresponsive to conservative treatment and often require repeated surgical intervention. These scars represent a serious problem in skin therapy after the extensive damage. Just the impairment of processes of the…
ОБЗОР2016
Korshunov D.A., Korshunova Z.V., Kondakova I.V.
Energy supply of cells can be provided through both an oxygen-dependent pathway of mitochondrial oxidative phosphorylation and oxygenindependent glycolysis. Oxidative phosphorylation in the synthesis of ATP is more efficient than in glycolysis, and respectivel…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016
Kit O.I., Vodolazhsky D.I., Maksimov A.Yu., Lazutin Yu.N., Pyltsin S.P., Leyman I.A., Makueva A.M.
Introduction. EGFR mutation and EML4-ALK fusion are the most clinically significant genetic alterations in non-small cell lung cancer. Numerous studies have been devoted to EGFR mutations and their association with phenotypic clinical and pathological characte…
ОБЗОР2016
Zastrozhin M.S., Lepakhin V.K., Sychev D.A, Grishina E.A., Smirnov V.V., Savchenko L.M., Bryun E.A., Sorokin AS, Naumova A.G, Ivanyuk A.V.
The use of haloperidol in clinical practice is often accompanied by the development of severe unwanted adverse side effects from the side of various organs and systems. In the narcological practice the use of antipsychotic drugs is not seldom complicated by ex…
ПЕРЕДОВАЯ СТАТЬЯ2016
Paltsev M.A., Polyakova V.O., Linkova N.S., Paltseva E.M., Kvetnaia T.V., Zuev V.A., Kvetnoy I.M., Popuchiev V.V.
Alzheimer's disease being the socially significant neurodegenerative disease of the elderly, ranks 6th on the causes of death among somatic pathologies. The molecular mechanisms of Alzheimer's disease still remain unexplored until the end, and the efficacy of …
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016
Drobintseva A.O., Kleimenova T.S., Polyakova V.O.
Introduction. Kisspeptin, was originally identified as a protein suppressing metastasis, since it has the ability to inhibit the migration of melanoma cells. It was established that KISS1 / KISS1R has a significant impact on the process of puberty and regulate…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016
Panteleyev A.A., Sytina E.V., Chaban E.A., Paltsev M.A.
Introduction. Amniotic tissue sheath is unique in its wound-healing properties, including anti-fibrotic, immunosuppressive and antibacterial features, as well as in its ability to stimulate cell proliferation and migration. These properties are further complem…
ОБЗОР2016
Dolzhanskiy O.V., Pigolkin Yu.I., Paltseva E.M., Korostylev S.A., Kanivets I.V., Fedorov D.N.
On the basis of published data there were assessed criteria of eligibility of paraffin blocks with malignant tumors for the decision of a question of the genetic identity of the samples. In order to prevent potential errors it’s not recommended to use the carc…
ОБЗОР2016
Chubarova S.V., Yakovchuk I.А., Kraposhina А.Yu., Soloveva I.A., Demko I.V., Salmina A.B.
The main purpose of the treatment of bronchial asthma is achievement and maintenance of the control over the symptoms of disease at optimal level. For this purpose in terms of basic therapy there is used inhalation of as glucocorticosteroids as well systemic g…
ОБЗОР2016
Komova E.G., Vavilin V.A., Ivanov M.K., Lyakhovich V.V.
The review highlights the problem of the influence of the genetic characteristics of patients in the dosage of anticoagulant drugs, the main adverse reaction of taking of which is the internal bleeding. Therapy with anticoagulant drugs is characterized by a wi…
ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016
Denisova A.B., Salmina A.B., Cherdantsev D.V., Grishchenko E.G., Zhegalov P.S.
Introduction. Gastric cancer is a global problem for the health systems worldwide. Today it takes the fourth place in the world in the morbidity and the second place in the mortality structure. In Russian Federation, almost 70% of gastric cancer cases are diag…