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Is the progression of tuberculosis possible against the background of antitumor therapy for lung cancer? Results of an experimental study

Kudryashov G.G., Vinogradova T.I., Zmitrichenko Yu.G., Krylova Yu.S., Dogonadze M.Z., Zabolotnyh N.V., Dyakova M.E., Esmedlyaeva D.S., Tochilnikov G.V., Nefedov A.O., Agafonov G.M., Yablonskiy P.K.

Aim of the study. The possibility of using antitumor drugs against the background of active tuberculosis is an unresolved problem of modern medicine. The aim of the experimental study was to study the course of tuberculosis infection against the background of …

BIOLOGICAL MODEL OF LUNG CANCER COMBINATION AND TUBERCULOSIS: DEVELOPMENT FOR PRECLINICAL STUDY OF RATIONAL COMBINATIONS OF TARGETED ANTITUMOR AND ANTITUBERCULOSIS THERAPY

Krylova Yu.S., Kudriashov G.G., Tochilnikov G.V., Vinogradova T.I., Dokhov M.A., Yablonskii P.K.

Introduction. Lung cancer occupies a leading position in the structure of mortality from cancer. Chronic inflammation characteristic of tuberculosis increases the risk of lung cancer. Currently, more and more information is emerging confirming the cause-and-ef…

USE OF MESENCHYMAL STEM CELLS IN COMPLEX TREATMENT OF DRUG-RESISTANT RENAL TUBERCULOSIS (EXPERIMENTAL STUDY WITH MORPHOLOGICAL CONTROL)

Vinogradova T.I., Esmedlyayeva D.S., Dyakova M.E., Muravyev A.N., Remezova A.N., Ariel B.M., Bogdanova E.O., Dogonadze M.Z., Zabolotnykh N.V., Yudintseva N.Yu., Polyakova V.O., Yablonskiy P.K.

Introduction. The use of mesenchymal stem cells (MSCs) is recognized as a promising direction for the treatment of diseases with a predominance of inflammation and sclerosis in the pathogenesis, which includes nephrotuberculosis (NT). Target. Studying the effe…

SYSTEM MATRIX METALLOPROTEINASE/INHIBITORS IN PATHOGENESIS OF INFILTRATIVE PULMONARY TUBERCULOSIS, DEPENDING ON THE RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS STRAINS FOR ANTI TUBERCULOSIS THERAPY

Esmedlyaeva D.S., Alekseeva N.P., Dyakova M.E.

Introduction. The search for molecular markers of adverse treatment outcomes in individuals with pulmonary tuberculosis (PT) is relevant due to the worldwide increase in drug resistance of Mycobacterium tuberculosis (MBT) strains to anti-tuberculosis drugs (PT…

THE EFFECT OF ANTITUMOR DRUGS ON THE COURSE OF TUBERCULOSIS IN THE EXPERIMENT

Kudriashov G.G., Vinogradova T.I., Zmitrichenko Yu.G., Dogonadze M.Z., Zabolotnyh N.V., Dyakova M.E., Esmedlyaeva D.S., Gavrilov P.V., Azarov A.A., Tochilnikov G.V., Nefedov A.O., Krylova Yu.S., Yablonskii P.K.

Introduction. Lung cancer and tuberculosis, make a significant affect to the morbidity and mortality of the population in Russia and in the world. Strategy of medication therapy has not been developed for cases when these diseases are combined. The aim of the …

THE EFFECT OF TUBERCULOSIS ON THE COURSE OF LUNG CARCINOMA IN THE EXPERIMENT

Kudriashov G.G., Nefedov A.O., Tochilnikov G.V., Zmitrichenko Yu.G., Krylova Yu.S., Dogonadze M.Z., Gavrilov P.V., Azarov A.A., Davydenkova E.A., Vinogradova T.I., Yablonskii P.K.

Introduction. One of the problems of modern medicine is the low efficiency of treatment of patients with a coexistence of lung cancer and active tuberculosis. Optimal treatment regimens for coexistence pathology have not been developed at present. In recent ye…

SIGNALING MOLECULES OF TUMOR TRANSFORMATION IN TUBERCULOSIS

Krylova Yu.S., Kudriashov G.G., Nefedov A.O., Dokhov M.A., Zakharchenko A.O., Yablonskii P.K.

The review is devoted to the analysis of modern ideas about the molecular mechanisms of tumor transformation in tuberculosis; signal molecules are described, which may be biomarkers and targets for optimizing personalized diagnosis and targeted therapy of the …

COMPENSATORY MUTATIONS AS A MECHANISM FOR PRESERVING VIRULENCEAND VIABILITY OF DRUG-RESISTANT FORMS OF MYCOBACTERIUM TUBERCULOSIS

Tuberculosis remains one of the leading causes of death from infectious diseases in the world. According to WHO data, tuberculosis is diagnosed annually in more than 100 million people and causes 4.5 thousand deaths. Despite a steady decline in the main epidem…

FEATURES OF IRON EXCHANGE IN PATIENTS WITH LUNG TUBERCULOSIS (REVIEW OF LITERATURE)

Borodulina E.A., Yakovleva E.V.

Iron is an essential trace element not only for the human body, but also for some microorganisms, including mycobacterium tuberculosis. Being strict aerobes, mycobacteria receive iron from the human body using the siderophore transporter system. Iron deficienc…

EVOLUTIONARY SIGNIFICANCE OF NON-SYNONYMOUS SUBSTITUTIONS FOR MYCOBACTERIUM TUBERCULOSIS OF URAL GENOTYPE

Sin’kov V.V., Ogarkov O.B., Mokrousov I.V., Zhdanova S.N.

Introduction. Russian population of Mycobacterium tuberculosis includes both highly virulent and less virulent strains; the Ural genotype makes an example of the latters. The aim of study was investigation of the most significant synonymous and non-synonymous …

THE STUDY OF THE EFFECT OF INTERACTION BETWEEN GENES, ASSOCIATED WITH PHENOMENON OF DRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS COMPLEX

Ludannyy R.I., Alvarez Figueroa M.V., Prokopenko A.V., Valdokhina A.V., Shipulin G.A.

Introduction. The phenomenon of drug resistance of Mycobacterium tuberculosis complex is extremely complicated. The determination of the genetic changes is not always able to explain reasons of this effect clearly. The aim of the study. Molecular genetic analy…