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Molecular Medicine
Found: 52
The study is devoted to the identification of changes in the proteomic profile of senescent mesenchymal stromal cells of adipose tissue, which determine the modulation of the macrophage phenotype and are involved in the pathogenetic cascade of the formation of…
Background. University entry is accompanied by abrupt changes in social environment, lifestyle and cognitive load, which challenge stress-response systems, the autonomic nervous system (ANS), and immune-metabolic homeostasis. In Russian clinical practice, this…
Introduction. Short peptides are considered a promising class of geroprotective agents capable of modifying key molecular mechanisms of aging, from epigenetic regulation of gene expression to maintenance of neuroendocrine and antioxidant homeostasis. Laborator…
Introduction. In general, the physiological response of tissues to external stresses is not linear in accordance with Hooke's law. Biological tissues are known to exhibit a nonlinear relationship between stress and strain, although the origins of this nonlinea…
Introduction. Up to 20% of tuberculosis patients suffer from malignant neoplasms. In this case, the combination of both diseases in the lung is a particular problem. More than 60% of patients cannot complete combination therapy due to drug-resistant MBT. The a…
Introduction. In present, the medical community continues to study the impact of coronavirus infection on various organs and systems of the body. Infection with the SARS-CoV-2 virus causes multifaceted pathological processes and, among other things, affects th…
Introduction. Alcohol abuse is associated with telomere shortening. There is no convincing evidence of a “safe” level of alcohol consumption in this regard. Long-term studies in rodents are not feasible, and clinical trials with the administration of alcohol t…
Introduction. The receptor for advanced glycation end products (RAGE) is a pattern recognition receptor that is highly expressed in healthy lungs and performs homeostatic function there. However, the exact mechanisms of development of these diseases remain unk…
Introduction. To date, the problem of studying the neuropeptide system of regulation of adaptive processes is relevant, since the stress reaction is a trigger for the occurrence of various diseases, in particular depression. Corticoliberin is considered as the…
Introduction. Treatment of the coexistent pathology of lung cancer and tuberculosis remains the prerogative of experimental research, since the optimal treatment strategy for the coexistence of these two diseases has not yet been developed. The purpose was to …
Introduction. It is known that in the pathogenesis of caries and non-carious lesions of teeth, an important role is played by enamel resistance, which is determined by numerous factors, among which the structure and physical and mechanical properties of tooth …
Introduction. In Kyrgyzstan about 60% of the adult population suffers from lipid metabolism disorders of varying degrees. Early identification of persons at increased risk of developing obesity is of great importance, which can be achieved through the study of…
Introduction. To this date the search for new substances with antitumor activity is an urgent task of pharmacology and medicine. Carrageenans are sulfated galactans of red algae, they are promising substances for the basis of future drugs, as well as for the c…
Introduction. The worldwide trend towards green technologies has increased interest in the development and use of natural, highly-efficiency and inexpensive plant antioxidants to replace existing synthetic ones. Purpose of the study. study of the composition o…
Introduction. Single nucleotide polymorphisms rs34643859 of the KCNS1 gene, rs12804550 of the SCN4B gene, and rs4514993 of the SCN11A gene were revealed in the analysis of the results of whole exome sequencing of a group of young man died by sudden cardiac dea…
Introduction: Urate nephrolithiasis is a common form of urolithiasis. The development of new methods for pharmacological correction of this disorder requires their practical laboratory assessment. So far, it is necessary to determine the most typical biochemic…
Introduction: nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. But it remains unclear what factors influence the progression of the disease. It is interesting to study the influence of the genetic aspect on the course of NAF…
Introduction. The oral cavity is the beginning of the human digestive system and the presence of pathological changes in it: a shift in the dynamic balance, composition, and types of microorganisms inhabiting the oral cavity; color change; the appearance of pa…
Introduction. The formation of neurofibrillary plexuses and the accumulation of senile plaques in the parenchyma and cerebral vessels are the key pathological signs of Alzheimer’s disease presenting a neurodegenerative disease. The main component of senile pla…
Currently, glioblastoma is an extremely malignant tumor, for which treatment only temozolomide is relatively effective. Aim to study the expression and variants of coexpression of transcription factors NeuroD1, Prox1, FoxM1, somatostatin receptors of the 2nd a…