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Molecular predictors of efficacy of single-stranded yeast RNA and ascorbic acid complexes: from critical quality attributes to personalized immunomodulation

Potupchik T.V., Ermolaev V.V., Generalov S.V., Alikin Yu.S., Evert L.S., Kurbanova D.V., Shevchuk A.S., Omarova L.S.

Introduction. Single-stranded yeast RNA–ascorbic acid complexes are of interest as a class of natural immunomodulatory systems combining activation of innate immune pattern-recognition receptors with redox-modulating and epigenetic effects of vitamin C. Russia…

Molecular and biological characteristics of tumor cells in testicular embryonal carcinoma explants

Demyashkin G.A., Belokopytov D.V., Shchekin V.I., Borovaya T.G., Rostovskaya V.V., Tsomartova D.A., Pyatigorskaya N.V., Filippova O.V., Maksarova D.D., Mirontsev A.V.

Introduction. Personalized treatment strategies for embryonal carcinoma, a germ cell tumor, are crucial due to the inherent heterogeneity of the tumor. Existing in vitro models inadequately reflect the native tumor microenvironment. Ex vivo organ culture (EVOC…

THE POSSIBILITIES OF TELEMEDICINE TECHNOLOGIES TO PROVIDE A PERSONALIZED APPROACH IN CARDIOLOGY THROUGH THE USE OF WEARABLE DEVICES

Seliverstov P.V., Salikova S.P., Fedorets V.N., Kutsenko V.P., Shevyakov A.A., Samarskiy I.A., Levitskiy N.M., Akhmad K.A.

Cardiovascular diseases remain one of the main causes of hospitalization, disability, and mortality. The usual monitoring model and rare face-to-face visits often do not keep up with the actual clinical dynamics. This partly explains the growing interest in we…

YEAST RNA AS A SOURCE OF IMMUNOMODULATORY NUCLEOTIDES: FROM BIOCHEMISTRY TO CLINICAL APPLICATION

Potupchik T.V., Alikin Yu.S., Generalov S.V., Ermolaev V.V., Kudlay D.A., Ksanaeva J.A., Banar L.S., Makhova A.A.

Introduction. Yeast RNA is considered a promising class of natural immunomodulators that has been studied in Russian biomedical science since the Soviet period. High-molecular-weight RNA fractions from Saccharomyces cerevisiae exhibit pronounced immunostimulat…

FEATURES OF SHIFTS IN THE INDICATORS OF IMMUNE-ANTIOXIDANT STATUS IN RESIDENTS OF THE KRASNODAR TERRITORY SUFFERING FROM POLLINOSIS

Pavlyuchenko I.I., Klimenko Y.V., Golantsev A.S., Kokov E.A., Solomko A.A

Background. Pollinosis is a progressive allergic disease mediated by an IgE-dependent reaction associated with the activation of inflammatory processes, oxidative stress and lipid peroxidation, which affects, first of all, the membrane structures of various ce…

Synthesis and study of a triple chelated iron complex with folic acid and L-valine.

Gvozdenko A.A., Yasnaya М.А., Blinova A.A., Vlasov А.А., Kolodkin M.A.

Objective. Mixed organometallic complexes containing amino acids and water-soluble vitamins as ligands are promising research subjects in organic and physical chemistry. The practical applications of these compounds may include medicine, where they are conside…

Selenium: biochemical role and the importance of balance in the human body

Deeva T.A., Tyagunov E.G., Zolnikova O.Yu.

The aim of this review is to systematize current knowledge on the role of selenium in biochemical processes and in the development of diseases associated with its deficiency or excess. Material and methods. A comprehensive search and analysis of publications f…

Synergism of ascorbic acid and RNA interferon inducers in antiviral immunity activation: molecular mechanisms and therapeutic perspectives

Potupchik T.V., Alikin Yu.S., Generalov S.V., Evert L.S., Tymchuk V.I., Khalakoeva D.A., Abdullaeva S.R., Spitsyn А.А

Introduction. Ascorbic acid (vitamin C) is an essential cofactor of numerous enzymatic reactions and possesses pronounced antioxidant properties. Recent years have seen accumulating evidence of its immunomodulatory effects, particularly the ability to potentia…

Effects of short peptides on the molecular mechanisms of aging in laboratory primates

Trofimova S.V., Kuznetsova T.G., Trofimov A.V.

Introduction. Short peptides are considered a promising class of geroprotective agents capable of modifying key molecular mechanisms of aging, from epigenetic regulation of gene expression to maintenance of neuroendocrine and antioxidant homeostasis. Laborator…

Blood exosomes of patients with malignant neoplasms of bones and articular cartilage: connection with tumor progression and practical value in clinical medicine

Olgin O.E., Zheravin A.A., Aliev M.D., Choynzonov E.L., Chernyshova A.L., Tamkovich S.N.

Relevance. Primary malignant neoplasms of bones and articular cartilage account for about 0.2% of all cancer cases and are characterized by an aggressive course, high tendency to metastasize, and resistance to therapy, which leads to unsatisfactory survival ra…

Serotonin as a modulator of neurogenesis processes in post-traumatic stress disorder

The purpose of this review is to discuss the role of serotonin in the processes of neurogenesis in the hippocampus in post-traumatic stress disorder. Full-text materials were searched in Medline (PubMed) and Scopus databases over the past 15 years. Results. Co…

Polypragmasy in elderly and senile patients with chronic kidney disease: START/STOP criteria in elderly and senile patients taking DOAC

Kondrahin A.P., Silina E.G., Chernyaeva M.S., Maksimov M.L., Belokopytov A.S., Babichev A.N., Smirnova Yu.E., Martynova S.A., Schnаider K.O.

Introduction. Thanks to the achievements of modern medicine, it was possible to significantly increase the life expectancy of the population. Molecular mechanisms of aging include telomere shortening, DNA damage accumulation, mitochondrial dysfunction, leading…

Indicators of oxidative stress in adolescents with migraines

Kostyuchenko Yu.R., Evert L.S., Potupchik T.V., Morozkina A.E., Golubev V.I., Gasanova N.G.

Introduction. To date, there are a number of relevant studies devoted to changes in the LPO-AOP system indicators in adolescents and young adults with migraine. However, specific quantitative data and relationships between LPO-AOP indicators and migraine requi…

Biochemical markers of inflammation in drug-resistant tuberculous meningitis (experimental study)

Dyakova M.E., Vinogradova T.I., Ariel B.M., Esmedlyayeva D.S., Panteleev A.M., Blum N.M., Mukhametshina E.R., Dogonadze M.Z., Kurdoyak A.C., Zabolotnykh N.V., Lavrova A.I., Vishnevskiy A.A., Yablonskiy P.K.

Introduction. The determination of inflammatory markers used to monitor the course of the disease and monitor the effectiveness of treatment. Goal. To evaluate biochemical markers of inflammation in cerebrospinal fluid (CSF) and blood serum in experimental men…

Sirtuin expression in skin fibroblasts: pharmacomodulatory effect of quercetin

Kosova A.D., Mironova Е.S., Belova Yu.I., Drobintseva A.O., Khabarov V.N.

Introduction. Sirtuins (SIRTs) are NAD+-dependent histone deacetylases involved in the intracellular regulation of multiple biological processes including DNA repair, autophagy, inflammation, oxidative stress defence and metabolism associated with age-associat…

The Role of P2X7 Receptors in the Pathogenesis of Depression and Autism Spectrum Disorders

Panyukov V.A., Zakharova V.A., Malinovskaya N.A., Shogenov Z.I., Nicheporenko Yu.A., Shikhmagomedova A.R.

Introduction. Purinergic signaling pathways in brain cells can play an important role both in physiological conditions and in depression and autism spectrum disorders. The purpose of this literature review was a systematic analysis of information in the modern…

Рroliferotropic effect of peptides in liver organotypic tissue culture of different age rats

Ryzhak G.A., Chalisova N.I.

Introduction. One of the actual task of modern biology and medicine is the creation of bioregulator preparation, which have the proliferotropic effect on the internal organs of organism. Purpose of study. Study of proliferotropic effect of short peptides and p…

Interaction in the PAMPs – mucosal barrier – cytokines system in children with obesity

Kirilina I.V., Rumyantsev S.A., Gaponov A.M., Khusnutdinova D.R., Grigorieva T.V., Teplyakova E.D., Shestopalov A.V.

Introduction. The significant increase in obesity among children and adolescents necessitates the search for ways to prevent and treat it. Inflammation in obesity is the main mechanism leading to comorbid changes. Aim of the study. To establish correlations be…

The Impact of Low Doses of Ethanol on the Taxonomic Composition and Biodiversity of the Microbiota in the Small and Large Intestines of C57Bl6 mice

Laskina T.A., Zabolotneva A.A., Kharchev D.N., Shestopalov A.V.

Alcohol consumption has a detrimental effect on human health and is associated with various pathological changes in the body. In addition to the toxic effect on various tissues and organs, ethanol and its metabolites contribute to persistent changes in the com…

Effect of the S-nitrosoglutathione nitric oxide donor on the relative amount of P-selectin in vitro

Korotkova N.V., Kalinin R.E., Suchkov I.A., Abalenikhina Yu.V., Mzhavanadze N.D., Nikiforov A.A., Fomina D.I.

Introduction. Studying the effect of the nitric oxide (II) donor, S-nitrosoglutathione, on the relative amount of selectin P in HUVEC cell lysates in vitro may contribute to fundamental understanding of the effect of the nitric oxide system on the adhesive fun…