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Molecular Medicine
Found: 10
Introduction. Arterial hypertension (AH) and obesity form a common cardiometabolic phenotype, in which hemodynamic overload, dysfunctional adipose tissue, estrogen deficiency, dyslipidemia, endothelial dysfunction, vascular remodeling, and electrophysiological…
Introduction. Obesity can no longer be adequately described by body mass index alone. Similar BMI values may coexist with different fat distribution, inflammatory burden, neuroendocrine dysregulation, psychobehavioral traits, and risks of organ dysfunction. Ob…
The study is devoted to the identification of changes in the proteomic profile of senescent mesenchymal stromal cells of adipose tissue, which determine the modulation of the macrophage phenotype and are involved in the pathogenetic cascade of the formation of…
Introduction. Leptin is a representative of biologically active compounds produced by adipose tissue – adipokines. The traditional material for his research is blood. Saliva is a local secret of the glands of the initial part of the digestive tract, which has …
Introduction. Excess and lack of adipose tissue are associated with a violation of its functions, the mass of adipose tissue and its distribution play an important role in the development of metabolic disorders. The study of the influence of the main factors o…
Introduction. The brain injury induced during radiotherapy and chemotherapy is largely dependent on a disruption of neurogenesis in the subgranular zone of the dentate gyrus in the hippocampus as a result of the neural stem cells (NSCs) damage. The aim of the …
The review presents results of clinical and experimental investigations, revealed leptin’s role in the mechanisms of morphological and physiological development of the fetus and newborn. This review summarizes many of the published reports about the leptin’s r…
The role of key adipokines (leptin, adiponectin, resistin, visfatin, apelin, omentin) had been assessed as important factors for perinatal complications in mother with disorders of carbohydrate metabolism. The survey based on the analysis of literature data. H…
Introduction. According to the current understanding, oxidative stress plays a key role in the mechanisms of diabetes mellitus of types 1 and 2 emergence and development of its complications; formation of oxidative stress is accompanied by defective uptake of …
The article reviews modern data on the participation of signaling molecules in the pathogenesis of obesity. This review provides the detailed description of the functional morphology of adipose tissue as the major endocrine and immune organ. The imbalance in p…