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Molecular Medicine
Found: 5
Introduction. Among malignant tumors bladder cancer (BC) ranks fifth in the prevalence rate. In the average each year 20% of BC patients die, but in the case of the making diagnosis at the early stages of the disease, survival rate of patients is increasing.Cy…
Introduction. Mutations in the tumor suppressor gene TP53 are observed approximately in the half of all human malignancies. In bladder cancer (BC), ТР53 molecular alterations were shown to be associated with more aggressive tumor phenotype; however their clini…
Introduction. Interactions of exposed on the tumor cell surface or circulating in the bloodstream molecules MICA with activating receptor NKG2D play an important role in the regulation of antitumor immune response. Accumulation of soluble MICA compromises NKG2…
Introduction.Transitional cell carcinoma of the bladder is the second most common malignancy of the genitourinary tract. Cystoscopy and urine cytology are the traditional most used techniques for diagnosis and surveillance of superficial bladder cancer. Urinec…
The paper presents the results of our own investigation of abnormal methylation of tumor suppressor genes RASSF1A, P16, CDH1, LAMC3, DAPK in tumors and non-tumor tissues obtained from 64 patients with superficial bladder cancer. The purpose of the research is …