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Molecular Medicine
Found: 15
Relevance. PARP inhibitors (PARPi), have emerged as a significant development in the treatment of high-grade serous ovarian cancer that is associated with mutations in BRCA1/2 and genes of other homologous recombination proteins. These drugs exploit synthetic …
Introduction. Yeast RNA is considered a promising class of natural immunomodulators that has been studied in Russian biomedical science since the Soviet period. High-molecular-weight RNA fractions from Saccharomyces cerevisiae exhibit pronounced immunostimulat…
Introduction. Rabies is currently a rare but deadly viral disease transmitted through animal bites, mainly dogs. There is no standardized effective therapy for clinically manifest rabies. Patients with developed symptoms are mainly provided with palliative car…
Purpose of the review. The purpose of this review was to summarize the available relevant data on pathogenetic mechanisms in the formation of steroid resistance in severe bronchial asthma. Material and methods. The analysis of domestic sources on the CyberLeni…
Objective. To analyze the current state of preclinical and clinical studies in genome editing for neurodegenerative diseases, evaluate its potential impact on clinical practice, and examine ethical aspects of these technologies’ application. Material and metho…
The purpose of this review is to analyze current advances in the field of genome editing, their application for the modeling and treatment of neurodegenerative diseases, as well as to discuss current limitations and prospects for overcoming barriers in clinica…
Introduction. Alcohol abuse is associated with telomere shortening. There is no convincing evidence of a “safe” level of alcohol consumption in this regard. Long-term studies in rodents are not feasible, and clinical trials with the administration of alcohol t…
Relevance: COVID-19 is the accepted name for an acute respiratory disease caused by the SARS-CoV-2 coronavirus. The suddenness, speed of spread, severity, and high lethality of COVID-19 have led many of the drugs used in the early stages of a pandemic to be ba…
The purpose of the study was to analyze literature data on the use of mesenchymal stem cells as a conservative treatment of osteoarthritis. Material and methods. Literature search was carried out using keywords: traumatology, orthopedics, mesenchymal stem cell…
Mesenchymal stem cells (MSCs) are attractive in various fields of regenerative medicine due to their therapeutic potential and complex unique properties. Basic stem cell research and the global COVID-19 pandemic have given impetus to the development of cell th…
Due to the discovery of the proprotein convertase subtilisin/kexin type 9 (PCSK9) and the establishment of its role in lipoprotein metabolism, it became possible to deliver new groups of effective drugs for the treatment of dyslipidemia. The main function of P…
Progress in clinical research and medicine has contributed to a significant reduction in the worldwide mortality rate. Currently, the strategy of developed countries is directed at increasing expectancy and improving life quality. As a consequence, the modern …
The review of the literature on suicide gene therapy is presented. The therapeutic method is based on the transfection of tumor cells with a construct including the gene of the enzyme converting the substrate – the prodrug demonstrating low toxicity into a hig…
Modern methods of treatment of Parkinson's disease (PD) remain to be unsuccessful in cessation of the progression of neurodegenerative processes in the brain. The role of certain genes is proven by the etiology of PD, 10–15% of cases represent a monogenic dise…
Diabetes mellitus (DM) is a dangerous challenge to the entire international community and the priority of the first order national health systems of all countries over the world. The growing level of hyperglycemia in type 2 diabetes is associated with the incr…