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Molecular Medicine
Found: 15
Introduction. Sirtuins (SIRTs) are NAD+-dependent histone deacetylases involved in the intracellular regulation of multiple biological processes including DNA repair, autophagy, inflammation, oxidative stress defence and metabolism associated with age-associat…
Introduction. The use of mesenchymal stem cells (MSCs) is recognized as a promising direction for the treatment of diseases with a predominance of inflammation and sclerosis in the pathogenesis, which includes nephrotuberculosis (NT). Target. Studying the effe…
The article describes the results of an experimental study of tissue-engineering constructions based on lactic acid – poly-L,L-lactide, containing allogeneic cells of various tissue origin. Aim: to show experimentally the possibility of using an allogeneic tis…
Introduction. The work is devoted to study of new medication Novacutan SBio and Novacutan YBio as potential geroprotectors for biorevitalization of the skin. Klotho was used as a marker – to assess the overall aging of cells; MTH1 – the antioxidant status of c…
The task of molecular vital diagnosis is to search for peripheral tissues for the verification of biomarkers with the aim of optimization of diagnosis and evaluation of the effectiveness of treatment of socially significant diseases including cardiovascular pa…
Introduction. Skin aging is a natural process that cannot be stopped. However, there are many ways to help stop premature aging of the skin and reduce the signs that have already appeared. One of them is the subcutaneous administration of preparations containi…
Introduction. Currently, polymer nano-and microparticles are a promising material for the targeted delivery of drugs to human organs and tissues. The influence of these particles on humoral and cellular immune responses has not been studied. The aim of the stu…
Introduction. The Alzheimer disease (AD) is the socially important neurodegenerative disease. The promising way of the early lifetime diagnosis of the AD is the investigation of the expression of signal molecules by cells in a cerebrospinal fluid, blood lympho…
Introduction. Multihormonality is an ability of pituitary cells to produce more than one hormone. A great number of adenomas are multihormonal in the actual practice. We hypothesize cells of a normal pituitary gland to secret several hormones simultaneously. O…
Introduction. The minor population of Sertoli cells (SCs) from the transitional zone (TZ) of adult mouse testis called as TZ SCs is capable of active proliferation in culture and, at the same time, expresses all key SC markers. It could be an optimal source of…
Introduction. The assessment of placental dysfunction in clinical practice remains to be subject of debates, the search of sustaining morphological markers continues. The aim of the study was to find the correlation between the expression of vimentin and place…
Introduction. Alzheimer's disease (AD) is a socially important neurodegenerative disease. The prevalence rate of AD is increasing over recent years. According to the hypothesis concerning AD to be a systematic disease its manifestation can be detected in vario…
Introduction. Significance of chronic parodontitis is determined by not only of the degree of the prevalence rate, severity of the disease, but also by the low efficacy of the treatment and diagnosis at the early stage of disease. Nowadays there are not comple…
Introduction. Biomimetic peptides – are synthetic compounds which are identical to amino acid sequence that are synthesized by organizm, which can interact with growth factor receptors and provide antiaging clinical effect. The aim of the study. Investigation …
Introduction. Understanding of molecular and cellular mechanisms of vessels aging is the base of new approach creating of drugs for cardio-vascular pathology treatment. The goal of this work is the investigation of molecular and cellular mechanisms of vessels …