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Molecular Medicine Peer-reviewed scientific journal

Found: 4

ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2016

SEX HORMONES AS REGULATORS OF THE LEVEL OF GROWTH FACTORS IN TUMOR TISSUES IN POLYNEOPLASIA OF FEMALE REPRODUCTIVE ORGANS

Introduction. Sex hormones are known to influence on synthesis of growth factors in breast and uterus tumors, but their correlation in polyneoplasias is poorly studied. The aim of the study. The analyze local steroidogenesis, synthesis of growth factors and th…

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ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015

INSULIN-LIKE GROWTH FACTORS AND SEX HORMONES IN TUMOR TISSUE IN POLYNEOPLASIAS OF FEMALE REPRODUCTIVE ORGANS

Introduction. IGF-1R in breast cancer tumor tissue was shown to be expressed in large quantities in comparison with benign tumor or normal breast tissue. At the same time, IGF-1 stimulates proliferation of normal and tumor breast cells. The aim of the study. T…

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ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ2015

CHARACTERISTICS OF STEROIDOGENESIS IN THE TUMOR AND SURROUNDING TISSUES IN EXPERIMENTAL MELANOMA B16

Introduction. Hormonal aspect in the pathogenesis of melanoma development is still poorly studied. Tumor transplantation to experimental animals allows to study the effect of malignant process on different systems and organs, detect the saturation of tumor and…

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Research article2013

THE MECHANISM OF TOLERANCE OF THE ESTROGEN-INDEPENDENT BREAST CANCER CELLS TO HYPOXIA:THE ROLE OF SNAIL1 AND BETA-CATENIN, THE EPITHELIAL-MESENCHYMAL TRANSITION PROTEINS

The main goal of the project was to study the heightened tolerance of the resistant breast cancer cells to hypoxia. Two in vitro cultured breast cancer cell lines, the estrogen-dependent MCF-7 cells and the resistant ER-negative HBL-100 cells were used in the …

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