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Molecular Medicine
Found: 73
Introduction. Glutamate receptors are involved in modulating key T-lymphocyte functions, including proliferation, chemotaxis, and others. In the context of the immunopathogenesis of multiple sclerosis (MS), studying the mechanisms underlying these effects is o…
Introduction. Glutathione (GSH) is a key intracellular antioxidant involved in maintaining redox homeostasis, detoxifying xenobiotics, regulating immune and neurotransmitter systems, and supporting protein folding and degradation. Depletion of GSH is associate…
Introduction. Thanks to the achievements of modern medicine, it was possible to significantly increase the life expectancy of the population. Molecular mechanisms of aging include telomere shortening, DNA damage accumulation, mitochondrial dysfunction, leading…
Introduction: Studying the relationship between functional dyspepsia and gut microbiota will provide insight into the role of individual microorganisms and their metabolic products in the development of this pathology. The aim of the study was to analyze the m…
Relevance. Iron deficiency anemia is a disease present all over the world and maintaining a high incidence rate of both general and primary morbidity despite various options for correction and prevention of this pathology. Molecular genotyping opens up new pos…
Introduction. Allergic bronchial asthma (BA) is accompanied by activation of histamine H1/H4 receptors and variable response to antihistamines. The aim of this review is to analyze the molecular mechanisms of action of second- and third-generation antihistamin…
Introduction. Chronic lymphocytic leukemia (CLL) is the most common leukemia type in adults. CLL is characterized by significant changes in the patient's genome, including both various mutations and epigenetic changes. These changes currently play an important…
Introduction. Type 2 diabetes (T2D) is a chronic metabolic disorder. The number of diabetic people is increasing. AKT1 is a protein kinase and a participant in the PI3K/AKT/mTOR signaling pathway. The aim of the study was to analyze the association of polymorp…
Introduction. Thyroid disease is currently the most common among endocrine pathology. Hyperproduction of thyroid hormones is accompanied by stimulation of humoral reactions, contributing to the development of immune-mediated pathology under certain conditions,…
Introduction. DNMT3A is one of the most frequently mutated genes in acute myeloid leukemia (AML), and the R882H (G>A) substitution is one of the most common mutations in this gene. Restriction analysis and high resolution melting (HRM) analysis are the most co…
Despite significant advance in clear cell renal cell carcinoma treatment, immune checkpoint inhibitors (ICIs) still have limited therapeutic efficacy. Taking into account the resistance to immunotherapy, observed in malignant neoplasms, the search for predicti…
Introduction. Cervical cancer is one of the most common cancers of the female reproductive system, killing more than 250,000 women each year. The etiological agent that causes cervical cancer is well known. HPV infection with high oncogenic risk is the cause o…
Introduction. In Kyrgyzstan about 60% of the adult population suffers from lipid metabolism disorders of varying degrees. Early identification of persons at increased risk of developing obesity is of great importance, which can be achieved through the study of…
Objective: to analyze the literature data on HPgV infection caused by the Human pegivirus-1 virus (formerly hepatitis G, HGV, GBV-C). Materials and methods: search, by keywords, publications in Scopus, PubMed and Elibrary databases for the period from 1995 to …
MicroRNAs are defined as short non-coding molecules that regulate gene expression at the post-transcriptional level through complementary binding to the corresponding mRNA. This pairing leads to inhibiting of further translation by mRNA degradation, in other w…
Introduction. Single nucleotide polymorphisms rs34643859 of the KCNS1 gene, rs12804550 of the SCN4B gene, and rs4514993 of the SCN11A gene were revealed in the analysis of the results of whole exome sequencing of a group of young man died by sudden cardiac dea…
Introduction. Advances in biology and medicine in particular in the field of cell technologies allow us to test eye stem cells as an alternative to surgical treatment of corneal pathology. An option to increase the resistance of stem cells to adverse microenvi…
Background: The aim of this study was to investigate individual changes of protein expression in atherosclerotic plaques of coronary arteries at different stages of development of coronary atherosclerosis. Methods: The research object was homogenates of athero…
Sarcopenia is a progressive and generalized pathology of skeletal muscles of multi-factor nature. The present review focuses on the analysis of molecular genetic markers that may contribute both to sarcopenia risk formation and the variability of diagnosticall…
The article represents a literature review on the molecular genetic methods with routine histological material for clinical purposes within oncology service. The protocol to evaluate the quality of tumor tissue samples for molecular genetic studies is proposed…