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Molecular Medicine
Found: 55
The study is devoted to the identification of changes in the proteomic profile of senescent mesenchymal stromal cells of adipose tissue, which determine the modulation of the macrophage phenotype and are involved in the pathogenetic cascade of the formation of…
Background. University entry is accompanied by abrupt changes in social environment, lifestyle and cognitive load, which challenge stress-response systems, the autonomic nervous system (ANS), and immune-metabolic homeostasis. In Russian clinical practice, this…
Introduction. Posttraumatic stress disorder (PTSD) is presented as a systemic multilevel metabolic-immuno-psycho-neurological disorder with genetic predisposition and epigenetic influences, which radically changes the approach to its understanding and treatmen…
Introduction. Autoimmune oophoritis is one of the causes of premature ovarian insufficiency in 3–40% of cases. Representative diagnosis is possible only through histological examination of ovarian biopsy material, which complicates the identification of early …
Introduction. Bronchial asthma is a heterogeneous disease involving different phenotypes. The allergic phenotype is the most studied model of asthma. Identification of causally significant allergens by determining allergen-specific IgE is the key to precision …
Introduction. An urgent problem in biology and medicine is the identification of biologically active molecules that affect the cellular processes of proliferation and apoptosis in various tissues of the body. Purpose of the study. The purpose of this study was…
Introduction. Studies consider the immune and neuroendocrine systems as actively interacting with each other and priority participating in the complex maintenance of homeostasis. Immune processes are dependent on the functional activity of the endocrine system…
The purpose of the present study was to identify mast cells in brain sections of mice with neuroinflammation induced by intraperitoneal injections of LPS. Material and methods. The subjects of the study were nonlinear mice that received intraperitoneal injecti…
Introduction. An urgent problem in biology and medicine is the identification of biologically active molecules that affect the cellular processes of proliferation and apoptosis in various tissues of the body. Purpose of the study. The purpose of this study was…
One of the most important tasks of modern medicine is to recognize diseases at the preclinical stage, as well as to assess their development risks and their possible prevention. This dictates the need to use new, modern technologies aimed at the early detectio…
Introduction. The epidemiological process in tuberculosis is negatively affected by the HIV epidemic, the identification of vulnerable groups in relation to the unfavorable course of tuberculosis in combination with HIV infection will improve approaches to tre…
Introduction. In Kyrgyzstan about 60% of the adult population suffers from lipid metabolism disorders of varying degrees. Early identification of persons at increased risk of developing obesity is of great importance, which can be achieved through the study of…
Introduction. Endometriosis is a chronic inflammatory estrogen-dependent disease characterized by the presence of endometrial tissue outside the uterine cavity. The pathogenesis of endometriosis is not fully determined. The relevance of its study is due to the…
The majority of IgE binds with Fcε mast cells receptors. Repeated contacts between allergen and specific IgE on the surface of mast cells result in Fcε-receptors cross-linking, degranulation and release of inflammation mediators such as histamine, proteases, c…
Introduction. The worldwide trend towards green technologies has increased interest in the development and use of natural, highly-efficiency and inexpensive plant antioxidants to replace existing synthetic ones. Purpose of the study. study of the composition o…
Introduction. Early diagnostics of such oncological disease as cutaneous malignant melanoma is strictly important for the decrease of mortality. It is known that microRNA expression in melanoma cells and in bening melanocytic nevi is different, that can be use…
Background: The aim of this study was to investigate individual changes of protein expression in atherosclerotic plaques of coronary arteries at different stages of development of coronary atherosclerosis. Methods: The research object was homogenates of athero…
Introduction. The identification of molecular components contributes to the realization of the targeted properties of multicomponent drugs to study their molecular mechanism and therapeutic targets. The polypeptide complex isolated from cattle thymus (thymalin…
The article represents a literature review on the molecular genetic methods with routine histological material for clinical purposes within oncology service. The protocol to evaluate the quality of tumor tissue samples for molecular genetic studies is proposed…
Introduction. Molecular genetic research methods suggest the development of certain forms of pancreatitis and its complications. Aim of the study. Identification of risk factors for the development of acute forms of pancreatitis based on molecular genetic stud…