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Molecular Medicine
Found: 33
Introduction. Ovarian cancer is characterized by high mortality. Despite available diagnostic and therapeutic methods, patient survival remains unsatisfactory, especially for high-grade tumors, necessitating the exploration of new molecular targets. Heat shock…
Introduction: Biorevitalization is a modern method of injection cosmetology aimed at correcting age-related skin changes by introducing hyaluronic acid (HA) and additional biologically active components. The hyaluronic gel for microimplantation and mesotherapy…
Introduction. The interest in neutrophil extracellular traps (NETs) in various conditions, including pregnancy complications was increased over the last decade. Accompanied by gestational diabetes mellitus (GDM) hyperglycemia contributes to neutrophil’s activa…
Currently, the diagnosis of early stages of cutaneous T-cell lymphomas (CTCL) is one of the most challenging tasks in dermatology. This review is devoted to the analysis of new immunohistochemical (IHC) markers that could be considered diagnostic for the detec…
Relevance. Ectopic secretion, which occurs in the early stages of tumor development, is not only one of the first signs of a neoplasm, but can also indicate the severity of the oncological process. Purpose of the study: To evaluate the possibility of using the…
Introduction. Tuberculosis is a socially significant disease, which is based on chronic granulomatous inflammation with the formation of fibrosis. The signaling molecules CD44 and ICAM-1 play an important role in the process of migration of immune cells from t…
Introduction. Lung carcinoma is one of the most common cancers and the most likely cause of cancer mortality in the world. The use of the IHC method to determine the immunophenotype of tumor cells greatly facilitates the differential diagnostic search, allows …
Introduction. The formation of neurofibrillary plexuses and the accumulation of senile plaques in the parenchyma and cerebral vessels are the key pathological signs of Alzheimer’s disease presenting a neurodegenerative disease. The main component of senile pla…
Objective: a morphological study of the transcription factors NeuroD1, Nkx2.2, Isl1; somatostatin and chromogranin A in various forms of CH The methods included immunohistochemistry examination with antibodies to NeuroD1, insulin, somatostatin, ChrA, Nkx2.2, I…
Introduction. Inflammatory myofibroblastic neoplasm (IMN) of the spleen is extremely rare. It is often benign lesion, represented mainly by fusiform myofibroblasts and inflammatory cells (plasma, lymphocytes and eosinophilic granulocytes). Clinically, the sple…
Introduction. Neuroglia plays an important role in maintaining the stable functioning of the CNS. Of particular importance are neuroglial cells in the organization of the immune system of the brain, activating both with physical, physiological damage, and with…
Introduction. At present, signaling pathways involved in the development of innate and adaptive immune responses and comprising, inter alia, the interaction of pattern-recognizing receptors, such as TLR, with antimicrobial peptides associated with inflammation…
Introduction. The current direction of modern medicine is the development of new methods for non-invasive diagnosis of neurodegenerative diseases, in particular, Parkinson's disease. The goal of the investigation was the comparative analysis of α-synuclein and…
Introduction. Changes in the structural organization of the cell nucleus often precede the degeneration of the nerve cell. Histone H4 trimethylated on lysine 20 (H4K20me3) may act as one of the markers of neurodegenerative processes. The aim of this paper was …
Introduction. Multihormonality is an ability of pituitary cells to produce more than one hormone. A great number of adenomas are multihormonal in the actual practice. We hypothesize cells of a normal pituitary gland to secret several hormones simultaneously. O…
Introduction. The physiological state of the skin vasculature is largely determined by the influence of environmental factors, including the alteration of the oxygen partial pressure. Obviously, the epidermis, as the surface layer of the skin, should play a ke…
Introduction. Fibroadenomatosis (FAM) is a heterogeneous group of pathological conditions of the mo-Nochnoi gland, with hormone-dependent nature and different degree of risk maligni of the organization. The use of routine histological stains is not enough to d…
Introduction. Kisspeptin, was originally identified as a protein suppressing metastasis, since it has the ability to inhibit the migration of melanoma cells. It was established that KISS1 / KISS1R has a significant impact on the process of puberty and regulate…
Introduction. The transcriptional activity of hypoxia-inducible factor 1 (HIF1) not only drives cellular adaptation to O2 deficiency, but also plays an important role in the development and functioning of various organs and tissues. Data on the role of HIF reg…
Introduction. The central role in the pathogenesis of Crohn's disease (CD) is given an immune disorder. Communication immunohistochemical characteristics of the mucous membrane with the outcome of the disease has not been studied. The aim of the study. The aim…