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DECREASE IN ANG AND VEGF mRNA LEVELS DURING PROGRESSIVE ANGIOGENESISOF THE LIVER VENOUS SYSTEM OF WISTAR RATS IN EXPERIMENTAL CIRRHOSIS

Introduction. Currently, understanding the molecular mechanisms of pathological angiogenesis remains a fundamental problem in hepatology. The aim of this work was to find a relationship between the level of mRNA expression of the ang, vegf genes and angiogenes…

EXPRESSION RATES OF THE CASPASE 3,6,8 AND 9 GENES IN PERIPHERAL BLOOD LEUKOCYTES IN HEALTHY DONORS AND PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE IN THE ABSENCE OF HEPATOPROTECTIVE THERAPY AND AFTER THERAPY WITH URSODEOXYCHOLIC ACID

Kurbatova I.V., Dudanova O.P., Topchieva L.V., Larina A.A.

Introduction. The contribution of caspase-dependent apoptosis in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is not fully understood. One possible mechanism of hepatoprotective action of ursodeoxycholic acid (UDCA) is the suppression of apopto…

THE PROFILE OF MICRORNA EXPRESSION IN LIVER IN CHRONIC HEPATITIS C PATIENTS AND THEIR ASSOCIATION WITH CLINICAL PARAMETERS

Bovt P.A., Vishnevskaya T.V., Nurmukhametova E.A., Blokhina N.P., Deryabin P.G., Samokhvalov E.I., Kolobukhina L.V., Khlopova I.N., Kelly E.I., Malyshev N.A., AlkhovskyS.V.

Introduction. Hepatitis C virus (HCV) is a major risk factor for chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Molecular mechanisms of fibrogenesis are associated with the activation or inhibition of signaling pathways, which are controlling…

POLYMORPHISM OF GENES OF CYTOKINES OF IL-2 (T330G),IL-10 (S819T) AND IL10 (G1082A) IN CHRONIC VIRUS HEPATITIS C

Еmelyanova A.N., Vitkovsky Yu.A.

Summary. Polymorphism of cytokine genes IL-2 (T330G), IL-10 (S819T) and IL10 (G1082A) in chronic viral hepatitis C. The analysis of the frequency of occurrence T330G polymorphism in the promoter region of the gene IL-2, S819T and G1082A promoter region of IL-1…

COMPUTED TOMOGRAPHIC AND MORPHOLOGICAL COMPARISONSIN HEPATOCELLULAR CARCINOMA AT VARIOUS GRADES OF DIFFERENTIATION

Tumanova U.N., Dubova E.A., Karmazanovsky G.G., Shchegolev A.I.

The Use of the technique of contrast enhancement in spiral computed tomography (SCT) allows us to study the peculiarities of hemodynamics in the tumor tissue and thus facilitates the differential diagnosis. Сomparison of SKT data with the results of morphologi…