Abstract
Summary. Polymorphism of cytokine genes IL-2 (T330G), IL-10 (S819T) and IL10 (G1082A) in chronic viral hepatitis C. The analysis
of the frequency of occurrence T330G polymorphism in the promoter region of the gene IL-2, S819T and G1082A promoter region of IL-10
in healthy donors and patients with chronic hepatitis C at different stages of fibrotic changes Caucasian population of Trans-Baikal region.
Among patients with chronic hepatitis C at different stages of fibrotic changes more common G allele polymorphism of IL-2 (T330G), T allele
of the gene IL-10 (S819T) allele of the gene IL10 (G1082A). With no signs of chronic hepatitis C cirrhosis - homozygous TT polymorphism
IL-2 (T330G) was detected in 3%, GG – 3% of persons, the heterozygotic TG type – 94% prevailed. Among patients with HCV G allele
frequency of IL-2 gene (T330G) was 0,52, T allele among patients – 0,48 in the control group – 0,96). In patients with liver cirrhosis
frequency of the T allele of IL-2 gene (T330G) was 0,71, and allele G – 0,29.
Authors and affiliations
A.N. Еmelyanova, Yu.A. Vitkovsky
Chita State Medical Academy