Table of contents
Articles
CYTOTOXIC ACTIVITY OF THE IONOPHORE ANTIBIOTIC SALINOMYCINAND ITS COMBINATION WITH ANTICANCER PREPARATIONS AGAINST HUMAN MELANOMA CELLS
Salinomycin is referred to the group of the polyether antibiotics with ionophore activity. Currently salinomycin is considered as a potential anticancer drug. The aim of this work was to investigate the cytotoxic activity of salinomycin against MDR1+ (Mel-8) a…
THE GROWTH FACTORS AND ADHESION MOLECULES OF VESSEL ENDOTHELIUMAS TARGETS FOR CREATION OF PEPTIDE DRUGS AGAINST ATHEROSCLEROSIS
The expression of adhesion molecules (ICAM-1, E-selectin) and growth factors (PDGF, bFGF, TGF-β) was investigated in cultures of human endotheliual cells in health and atherosclerosis. Expression of ICAM-1, E-selectin, bFGF, TGF-β was shown to decline in ather…
MODIFICATION OF PROTEIN MOLECULES UNDER ENDOGENOUS INTOXICATIONAS A RISK FACTOR OF CHRONIC METABOLIC DISEASES
The enhancement of ligand properties of protein molecules treated by toxic reagents has been revealed in model experiments in vitro on ordered protein films. In patients with endogenous intoxication caused by metabolic disorders there were also detected protei…
CLINICAL SIGNIFICANCE OF E-CADHERIN AND KAI-1/CD82 EXPRESSION IN COLORECTAL CANCER
The prognosis of one of the most commonly occurring malignancies worldwide – colorectal cancer (CRC) – depends on the development of disease recurrence and distant metastases, most frequently detected in the liver. The aim of our research was to study the asso…
POLYMORPHISM OF GENES OF CYTOKINES OF IL-2 (T330G),IL-10 (S819T) AND IL10 (G1082A) IN CHRONIC VIRUS HEPATITIS C
Summary. Polymorphism of cytokine genes IL-2 (T330G), IL-10 (S819T) and IL10 (G1082A) in chronic viral hepatitis C. The analysis of the frequency of occurrence T330G polymorphism in the promoter region of the gene IL-2, S819T and G1082A promoter region of IL-1…
EVALUATION OF CYP2C9 ACTIVITY BY LOSARTAN TEST TO OPTIMIZETHE ANTICOAGULANT WARFARIN THERAPY IN PATIENTS AFTER HEART VALVE REPLACEMENT
Formation of an effective strategy for managing patients after implantation of an artificial heart valve (АНV), in order to prevent thrombotic complications is an important problem in cardiology. The use of indirect anticoagulants, including warfarin reduces t…
GENETIC ASPECTS OF ARTERIAL HYPERTENSION IN CHILDREN
The article presents results of a comparison of clinical, genealogical and molecular genetic data of the study of the role of gene polymorphisms of renin - angiotensin system (REN (G83A), AGT (M235T), AGTR1 (A1166C)) in children with hypertension, with taking …
GENOTOXIC EVENTS AND DISEASES
Based on literature and own data the role of genotoxic events in nosogenesis of hereditary, congenital and somatic diseases is considered. Special emphasis is paid to the analysis of significance of premutagenic DNA lesions and as well induced gene mutations i…
CD4+CD25+FOXP3+ T REGULATORY CELL ANALYSIS IN AUTOIMMUNE DISEASES
Regulatory T-cells CD4+CD25+FoxP3+CD127low (Тregs) belong to the family of CD4+ T-cell subpopulation. Tregs display the suppressive activity and play a critical role in regulation and maintenance of autotolerance and immune homeostasis. The generation and diff…