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Molecular Medicine Peer-reviewed scientific journal

Molecular Medicine

THE GROWTH FACTORS AND ADHESION MOLECULES OF VESSEL ENDOTHELIUMAS TARGETS FOR CREATION OF PEPTIDE DRUGS AGAINST ATHEROSCLEROSIS

Malinin V.V., Durnova A.O., Polyakova V.O.

Authors and affiliations

V.V. Malinin (1), A.O. Durnova (2), V.O. Polyakova (2)
1 -Medical-Biological Research-Industrial Complex «Cytomed»; 2 -The Research Institute of Obstetrics and Gynecology named after D.O. Ott of the North-West Branch of the Russian Academy of Medical Sciences, St. Petersburg, Russian Federation

Published
2013

Abstract

The expression of adhesion molecules (ICAM-1, E-selectin) and growth factors (PDGF, bFGF, TGF-β) was investigated in cultures
of human endotheliual cells in health and atherosclerosis. Expression of ICAM-1, E-selectin, bFGF, TGF-β was shown to decline in
atherosclerotic endothelium, but the synthesis of PDGF didn’t change. The investigation of biological effects of peptide Lys-Glu-Trp has
shown the possibility of its using as a potential drug for molecular target therapy of atherosclerosis.

Keywords

Authors and affiliations

V.V. Malinin (1), A.O. Durnova (2), V.O. Polyakova (2)
1 -Medical-Biological Research-Industrial Complex «Cytomed»; 2 -The Research Institute of Obstetrics and Gynecology named after D.O. Ott of the North-West Branch of the Russian Academy of Medical Sciences, St. Petersburg, Russian Federation

How to cite

Malinin V.V., Durnova A.O., Polyakova V.O. (2013). THE GROWTH FACTORS AND ADHESION MOLECULES OF VESSEL ENDOTHELIUMAS TARGETS FOR CREATION OF PEPTIDE DRUGS AGAINST ATHEROSCLEROSIS. Molecular Medicine, (3).

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