Table of contents
Articles
THE OBESITY: THE MOLECULAR MECHANISMS AND THE OPTIMIZATION OF TARGET THERAPY
The article reviews modern data on the participation of signaling molecules in the pathogenesis of obesity. This review provides the detailed description of the functional morphology of adipose tissue as the major endocrine and immune organ. The imbalance in p…
PLEIOTROPIC EFFECTS OF MULTIFACTORIAL DISEASE SUSCEPTIBILITY GENES
The article provides a brief overview of the evolution of views on the phenomenon of pleiotropy. We discuss with assessment of pleiotropic effects significance in the formation of human pathological states, above all – multifactorial diseases (MFD). Pleiotropi…
MOLECULAR MECHANISMS OF SEVERE ASTHMA
Abstract: This review summarizes the results of studies devoted to identification the dominant mechanisms of formation and persistence of inflammation in severe asthma. According to the latest research, the most likely causal factors and molecules that underli…
PROTEOMIC PATTERNS OF BIOLOGICAL FLUIDS IN PATIENTS WITH HEAD AND NECK SQUAMOUS CELL CARCINOMA
Head and neck squamous cell carcinoma is one of the aggressive forms of cancer, which often presents at advanced stages, being associated with poor prognosis and low survival rates. Therefore, the delivery new biomarkers for early cancer detection and predicti…
DETERMINATION OF DONOR SPECIFIC HLA ANTIBODIES IN THE EARLY POST-TRANSPLANT PERIOD
To assess the detection and prognostic significance of donor-specific HLA antibodies serum samples from 66 recipients were examined. Donor-specific antibodies (DSA) have been identified in the sera of 15 patients (22,7%). To assess the effect on DSA during the…
ENDOTHELIN-1 (LYS198ASN) GENE POLYMORPHISM IN PATIENTSWITH PERIPHERAL VITREORETINAL DEGENERATION IN TRANSBAIKALIA
The results of the study of endothelin-1(Lys198Asn) polymorphism in Transbaikalia region in patients of russian and buryat nationality with peripheral vitreoretinal degeneration are presented. In patients the frequency of Asn-allele is higher than in healthy c…
THE RISK ASSESSMENT OF DEVELOPMENT OF CHOROIDAL NEOVASCULARIZATIONIN AGE-RELATED MACULAR DEGENERATION
Aim. To study a method of risk assessment neovascular age-related macular degeneration (AMD) with the genetic and clinical risk factors. Methods. The study included 255 patients with neovascular AMD (NVAMD) and 119 subjects in control group. Diagnosis and stag…
Val66Met BDNF POLYMORPHISM IN PATIENTS WITH A HIGH RISKOF MORTALITY DUE TO STROKE AND SEVERE TRAUMATIC BRAIN INJURY
We have studied BDNF gene Val66Met polymorphism in patients with a high risk of mortality due to stroke or severe head injury. Genotype ValVal rate was higher than that of in the control group in the total sample of subjects (75,5% and 63,6%; χ2=4,63; df=1; p=…
ASSOCIATION OF IL-4Rα POLYMORPHISM WITH THE DEVELOPMENTOF IMMEDIATE HYPERSENSITIVITY REACTIONS TO BETA-LACTAM ANTIBIOTICS
The development of allergic reactions to beta-lactam antibiotics is largely determined by genetic factors. In this work, to study the association of gene polymorphisms IL-4Rα (rs1801275) with the development of immediate hypersensitivity reactions (RGNT) to be…
EXPERIMENTAL EVALUATION OF FUNCTIONALITY OF RADIOPHARMACEUTICAL 188RE-ZOLEDRONIC ACID
The results of biodistribution of intravenously administrated 188Re-zoledronic acid in rats’ body on the model of bone lesions (callus) are presented. Experiments showed that the complex of 188Re-zoledronic acid has the bone-seeking distribution (up to 31,8% I…