Abstract
Head and neck squamous cell carcinoma is one of the aggressive forms of cancer, which often presents at advanced stages, being
associated with poor prognosis and low survival rates. Therefore, the delivery new biomarkers for early cancer detection and prediction of
tumor response to target therapy seems to be necessary. The proteomic technologies allow to conduct the large-scale studies of changes in
protein profile of tissues and biological fluids, thus discovering new approaches to the laboratory diagnosis. Identified proteins can be used
as markers for early cancer detection and prediction of the chemotherapy response. Solution of the problems related to the interpretation of
data, different methodological approaches and incompleteness of many studies, allow to determine with sufficient certainty what proteins
can be suggested to use in clinical settings.
Authors and affiliations
G.V. Kakurina (1), I.V. Kondakova (1), E.L. Choinzonov (1,2)
1 -Cancer Research Institute Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russian Federation;
2 -Siberian State Medical University, Tomsk, Russian Federation