DETERMINATION OF DONOR SPECIFIC HLA ANTIBODIES IN THE EARLY POST-TRANSPLANT PERIOD

Khubutia M.Sh.; Borovkova N.V.; Doronina N.V.; Shmarina N.V.; Storozhev R.V.; Chudakova L.V.

Abstract

To assess the detection and prognostic significance of donor-specific HLA antibodies serum samples from 66 recipients were examined.
Donor-specific antibodies (DSA) have been identified in the sera of 15 patients (22,7%). To assess the effect on DSA during the early posttransplant
period, the results of treatment of 38 renal transplant recipients have been analyzed. that donor-specific HLA antibodies were
found to be accompanied by the development of rejection in 5 out of 8 recipients, that in two cases led to the loss of the graft. Among the 30
patients in whom no DSA were found, the graft rejection was diagnosed in 4 cases. The acute cellular rejection was recorded in three patients.
Thus, de novo generation of donor-specific HLA antibodies is a poor prognostic factor in terms of rejection and graft loss.

Keywords

Authors and affiliations

M.Sh. Khubutia, N.V. Borovkova, N.V. Doronina, N.V. Shmarina, R.V. Storozhev, L.V. Chudakova
N.V. Sklifosovsky Research Institute of Emergency Care, Moscow, Russian Federation

How to cite

Khubutia M.Sh., Borovkova N.V., Doronina N.V., Shmarina N.V., Storozhev R.V., Chudakova L.V. (2013). DETERMINATION OF DONOR SPECIFIC HLA ANTIBODIES IN THE EARLY POST-TRANSPLANT PERIOD. Molecular Medicine, (2).

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