Abstract
The enhancement of ligand properties of protein molecules treated by toxic reagents has been revealed in model experiments in vitro
on ordered protein films. In patients with endogenous intoxication caused by metabolic disorders there were also detected proteins with a
high content of trace elements (Fe, Zn), that are excluded from the organism with urine as foreign compounds. In all such patients there
were observed signs of chronic inflammatory processes. The presented results provide a basis of the following conception: the primary role in
tissue damage resulted from the auto-aggression mechanism is played by modified proteins with accumulated trace elements (Fe, Zn), which
aggravate the peroxide processes in tissues underlying chronic autoimmune inflammation. Such an approach explains the known in literature
phenomenon of protein deposition (particularly low-density lipoproteins) and trace elements (Fe, Zn) in the inflamed blood vessels, kidneys
and lungs in atherosclerosis.
Keywords
Authors and affiliations
E.A. Yurieva (1), V.S. Sukhorukov (1), A.D. Tsaregorodtsev (1), E.S. Vozdvizhenskaya (1), M.N. Kharabadze (1), N.N. Novikova (2), M.V. Kovalchuk (2)
1 -Institute of pediatric and child surgery; 2 -National research center «Kurchatov institute»