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Molecular Medicine
Found: 69
Introduction. Personalized treatment strategies for embryonal carcinoma, a germ cell tumor, are crucial due to the inherent heterogeneity of the tumor. Existing in vitro models inadequately reflect the native tumor microenvironment. Ex vivo organ culture (EVOC…
Introduction. Cancer patients have a high risk of developing venous thromboembolic complications, which worsen the outcomes of antitumor treatment and are the second leading cause of death after cancer progression. Objectives – to assess the effect of modern a…
This review systematizes current data on branched-chain aminotransferases (BCATs). Their molecular structure, classification as fold type IV pyridoxal phosphate (PLP)-dependent enzymes, and catalytic features are discussed in detail. The differences between th…
Introduction. Ovarian cancer is characterized by high mortality. Despite available diagnostic and therapeutic methods, patient survival remains unsatisfactory, especially for high-grade tumors, necessitating the exploration of new molecular targets. Heat shock…
Introduction. Lymphogenous metastasis is a key stage in the progression of gastric cancer. The practice of personalized treatment has historically been based on histological and molecular analysis of the primary tumor, while the molecular-genetic landscape of …
Background. University entry is accompanied by abrupt changes in social environment, lifestyle and cognitive load, which challenge stress-response systems, the autonomic nervous system (ANS), and immune-metabolic homeostasis. In Russian clinical practice, this…
Introduction. Chronic non-communicable diseases (NCDs) account for 75% of global mortality, while traditional treatment paradigm demonstrates inability to contain epidemiological burden. Artificial intelligence (AI) technologies combined with telemedicine enab…
Aim of the study. The possibility of using antitumor drugs against the background of active tuberculosis is an unresolved problem of modern medicine. The aim of the experimental study was to study the course of tuberculosis infection against the background of …
The purpose of the study. To analyze scientific data on the molecular targets and mechanisms of action of key natural bioactive substances used to support cancer patients after chemotherapy and radiation therapy in the framework of personalized medicine. Perso…
Introduction. Heat shock proteins (HSPs) are a group of highly prospective compounds that can be used in various branches of clinical medicine, such as neurology, pharmacology and oncology. Studying the content of these proteins in various parts of the brain o…
Introduction. Up to 20% of tuberculosis patients suffer from malignant neoplasms. In this case, the combination of both diseases in the lung is a particular problem. More than 60% of patients cannot complete combination therapy due to drug-resistant MBT. The a…
Introduction. Nanotechnology represents an innovative direction in cancer drug development, enabling the creation of effective drug delivery systems with enhanced therapeutic properties. Objective. To analyze the main types of nanoparticles used in oncology, e…
Relevance. The search for new antitumor drugs and their selective delivery directly to the tumor site is an important task of modern oncology. For these purposes, currently, the use of various nanoparticles as carriers of medicinal substances is of great impor…
Objective. To analyze current advances in nanotechnology applications for the development of targeted drugs in oncology, including their mechanisms of action and clinical application prospects. Material and methods. A comprehensive analysis of scientific liter…
Introduction. Angiogenesis regulators are of particular interest as new serum markers in cancer patients, since they reflect the intensity of tumor growth and metastasis. Currently, many works are dedicated to the study of vascular endothelial growth factor (V…
Introduction. Artificial intelligence (AI) technologies are becoming crucial in clinical diagnostics due to their ability to process and interpret large volumes of data. The implementation of AI for biomarker analysis opens new opportunities in personalized me…
Introduction. Oxidative stress (OS) occurs in various pathological processes, and acting as a nonspecific link in their pathogenesis. Less is known about its physiological role. The aim of study. Analysis of the results of world literature data and our own res…
Introduction. Lung cancer occupies a leading position in the structure of mortality from cancer. Chronic inflammation characteristic of tuberculosis increases the risk of lung cancer. Currently, more and more information is emerging confirming the cause-and-ef…
Introduction. Sequencing of single cells makes it possible to characterize the cellular and molecular composition of tissues, the state of DNA, RNA and expressed proteins. The «single-cell» sequencing method is gaining increasing popularity in modern biology a…
Introduction. Treatment of the coexistent pathology of lung cancer and tuberculosis remains the prerogative of experimental research, since the optimal treatment strategy for the coexistence of these two diseases has not yet been developed. The purpose was to …