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Molecular Medicine
Found: 19
Relevance. PARP inhibitors (PARPi), have emerged as a significant development in the treatment of high-grade serous ovarian cancer that is associated with mutations in BRCA1/2 and genes of other homologous recombination proteins. These drugs exploit synthetic …
Introduction. Ovarian cancer is characterized by high mortality. Despite available diagnostic and therapeutic methods, patient survival remains unsatisfactory, especially for high-grade tumors, necessitating the exploration of new molecular targets. Heat shock…
Introduction. Autoimmune oophoritis is one of the causes of premature ovarian insufficiency in 3–40% of cases. Representative diagnosis is possible only through histological examination of ovarian biopsy material, which complicates the identification of early …
Relevance. The review is devoted to the issue of aging and the relationship of the molecular processes of aging with the pathology of the reproductive system The aim of the study was to review the current understanding of aging, the mechanisms and role in the …
Introduction. Ovarian clear cell carcinoma (OCCC) is a subtype of epithelial ovarian cancer characterized by frequent mutations in the ARID1A gene and low sensitivity to standard-of-care chemotherapeutic agents. The aim of the study. To determine the role of A…
Introduction. The correct functioning of the circulatory system allows providing stability of the brain and prevents the progression of pathological processes. The search for prognostic markers which make it possible to predict the appearance and adverse cours…
Introduction. Breast cancer is the leading cancer type among woman of Azerbaijan population. Hereditary mutations of the BRCA1/2 genes are considered as high risk for appeared breast and ovarian cancers. In Azerbaijan BRCA1/2-related breast and ovarian cancer …
On the basis of published data there were assessed criteria of eligibility of paraffin blocks with malignant tumors for the decision of a question of the genetic identity of the samples. In order to prevent potential errors it’s not recommended to use the carc…
Introduction. Immunologic microenvironment of malignant tumors is likely to be significant in «tumor-host» interaction. The aim of the study. Сomparative analysis of systemic and local factors of cellular and humoral immunity in patients with ascitic forms of …
MicroRNAs (miRNAs) – small non-coding RNAs targeting multiple mRNAs – are posttranscriptional regulators of gene expression involved in carcinogenesis, metastasis, and invasion. MiRNAs expression is altered in various human tumors including ovarian cancer. Ana…
Introduction. Endometriosisis a commonovarianhormone-dependent diseasesin womenof reproductive age. Lack ofeffectiveness of treatmentof this diseasemay be associatedwith gapsof knowledgeabout the molecular mechanismsof its originand development. The aim of the…
Introduction: Insulin-like growth factors (IGFs), insulin-like growth factor-I receptor (IGF-IR), IGR-binding proteins (IGFBPs) and IGBP proteases can play an important role in the development of metastases in ovarian cancer. The relationship between IGF syste…
The most important event in the molecular biology of the last years is the discovery of the regulation of intracellular processes by micro RNAs – a product of complicated processing of precursor RNAs synthesized on nuclear genes, that are playing the key role …
Introduction. Kisspeptins (KP) are family of peptide mediators regulating function of gonadotrophic axis through the control of secretion of gonadotrophins at the central level. Also was shown that they are synthesized in other tissues and organs, where they h…
Introduction. Insulin-like growth factor signaling system plays a major role in the development and progression of various malignant tumors including ovarian cancer, and its components are considered as potential diagnostic and prognostic markers and objects o…
A literature review is devoted to the analysis of clinical significance of key factors of neoangiogenesis in ovarian cancer patients, their connection with the main clinical and morphological characteristics of the disease, prognosis, features an anti-angiogen…
Early diagnosis of ovarian cancer (OC) remains to be the actual problem in modern oncology due to the high mortality rate, asymptomatic course of the disease in the early stages and its aggressiveness. The aim was to study the genetic polymorphism of pathogene…
Publications devoted to the role of various representatives of matrix metalloproteinases (MMPs) family and their tissue inhibitors in ovarian cancer in differential diagnostics, prognosis and in the development of new treatment modalities are critically analyz…
Results of radioligand determination of epidermal growth factor receptor (EGFR) and radioreceptor assessment of EGF-like peptides’ (EGFLP) levels in the tumors of 44 ovarian cancer and 10 benign ovarian tumor patients are presented. Frequency of revelation and…