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COMPENSATORY MUTATIONS AS A MECHANISM FOR PRESERVING VIRULENCEAND VIABILITY OF DRUG-RESISTANT FORMS OF MYCOBACTERIUM TUBERCULOSIS

Tuberculosis remains one of the leading causes of death from infectious diseases in the world. According to WHO data, tuberculosis is diagnosed annually in more than 100 million people and causes 4.5 thousand deaths. Despite a steady decline in the main epidem…

STRUCTURALLY FUNCTIONAL ORGANIZATION OF THE GENOME OF A CLINICALLY SIGNIFICANT STRAIN HELICOBACTER PYLORI HP42K ISOLATED FROM THE PATIENT A HOSPITAL IN THE BELARUS REPUBLIC

Voropaev E.V., Baranov O.Yu., Valentovich L.N., Osipkina O.V., Zyatkov A.A., Bonda N.A., Voropaeva A.V., Platoshkin E.N., Mizura V.M., Shaforost A.S.

Introduction. The use of genomic approaches allows a detailed studying of the pathogenetic potential of H. pylori bacteria. The aim of the study. To investigate the genome structural and functional organization of the H. pylori isolated in the Republic of Bela…

OVEREXPRESSION OF APOPTOTIC ENDONUCLEASE ENDOG INHIBITS TELOMERASE ACTIVITY IN HUMAN CD4+ T CELLS

Vasina D.А., Zhdanov D.D., Orlova E.V., Orlova V.S., Pokrovskaya M.V., Aleksandrova S.S., Sokolov N.N.

Introduction. Alternative splicing of telomerase catalytic subunit hTERT (human Telomerase Reverse Transcriptase) regulates the telomerase activity. The increased expression of non-active spliced hTERT results in inhibition of telomerase. However, very little …

DEVELOPMENT OF MODULAR PEPTIDE CARRIER FOR TARGETED GENE DELIVERY INTO HUMAN TUMOR AND STEM CELLS

Bogacheva M.S., Egorova А.А., Baranov V.S., Kiselev A.V.

Introduction. Targeted gene delivery plays an exceptional role in the development of gene therapy. Peptide-based carriers are promising group of non-viral gene delivery vehicles due to biodegradability and easy structural and amino acid sequence modifications.…