Аннотация
Будучи профессиональными антигенпрезентирующими клетками, обладающими функциональной пластичностью, дендритные клетки (ДК) широко изучаются в доклинических и клинических исследованиях вакцин против различных видов злокачественных опухолей. В отношении некоторых из них была доказана эффективность. Тем не менее в мире еще не существует ни одной официально одобренной дендритноклеточной вакцины (ДКВ) для лечения аденокарциномы молочной железы (АМЖ). Знание и понимание основных функций ДК, а также разработка способов усиления эффекта подобных вакцин могут способствовать развитию этого направления. В представленном обзоре рассматриваются основные типы ДК с акцентом на их роль в патогенезе опухоли молочной железы, а также рассматриваются основные механизмы захвата, процессинга и презентации антигенов. Кроме того, значительное внимание уделяется существующим исследованиям, касающимся терапии АМЖ ДКВ, применяющимися как в качестве монотерапии, так и в комбинации с другими терапевтическими стратегиями.
Ключевые слова
Авторы и аффилиации
А.А. Чернышева(1), И.В. Чехонин(2), О.И. Гурина(2), профессор, И.И. Шепелева(2, 3), кандидат биологических наук, доцент, Т.Н. Попова(1), доктор биологических наук, профессор 1-ФГБОУ ВО «Воронежский государственный университет», Российская Федерация, 394018, Воронеж, Университетская площадь, 1; 2-ФГБУ «Национальный медицинский исследовательский центр психиатрии и наркологии им. В.П. Сербского» Минздрава Российской Федерации, Российская Федерация, 119034, Москва, Кропоткинский пер., д. 23; 3-ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Российская Федерация, 117997, Москва, ул. Островитянова, д. 1 E-mail: 79202208606@yandex.ru
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